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Dolichol phosphate mannose synthase (DPMS) is a critical mannosyltransferase involved in the posttranslational modification of proteins. At present, there is limited knowledge regarding the function of DPMS in breast cancer. In this study, silica analysis in multiple datasets found that dolichyl\u2010phosphate mannosyltransferase subunit 2 (DPM2) is an unfavorable prognostic marker, suggesting its oncogenic role. Cell counting kit\u20108 and apoptosis assays show that DPM2\u2010silenced cancer cells exhibit decreased growth potential and enhanced cell death rate. Further, transwell and wound healing assays show reduced invasion and migration capabilities in DPM2 knockdown groups, xenograft nude mice model demonstrated smaller tumor volume in DPM2 silenced BC cells. Then, the underlying downstream mechanism of DPM2 in BC was predicted and analyzed, highlighting classical tumorigenic pathways like JAK\/STAT signaling pathway and oxidative phosphorylation activated in the cancer group. Finally, ChIP\u2010seq analysis, expression correlation analysis, inhibitor treatment, and dual luciferase assays show that DPM2 is transcriptionally activated by estrogen receptor1 (ESR1). The results show that high expression of DPM2 mRNA is significantly correlated with shorter overall survival (OS) and disease\u2010free survival (DFS) in breast cancer patients, and in vitro knockdown of DPM2 can significantly inhibit the malignant phenotypes of cells, including proliferation, invasion, migration, and apoptosis. These results suggest that DPM2 may play an important role in breast cancer. Altogether, we first uncovered the tumorigenic and prognostic role of DPM2 in breast cancer, cellular assays, and bioinformatics analysis highlighted DPM2 as oncogene via inhibited cancer\u2010related signaling pathways in breast cancer. Besides, DPM2 is transcriptionally activated by ESR1, the signaling axis of ESR1\/DPM2 provides a new strategy for BC\u2010targeted therapy.<\/jats:p>","DOI":"10.1002\/tox.24059","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T07:54:13Z","timestamp":1701762853000},"page":"1737-1746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["RETRACTED:\n                    <scp>DPM2<\/scp>\n                    serve as novel oncogene and prognostic marker transactivated by\n                    <scp>ESR1<\/scp>\n                    in breast cancer"],"prefix":"10.1002","volume":"39","author":[{"given":"Jiahao","family":"Lu","sequence":"first","affiliation":[{"name":"Shanghai Putuo Central School of Clinical Medicine Anhui Medical University  Shanghai China"},{"name":"The Fifth School of Clinical Medicine Anhui Medical University  Anhui 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