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Our team has successfully patented and characterized a chicken\u2010liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH\u2010based supplement (GBHP01\u2122) against chronic alcohol consumption. Results showed that GBHP01\u2122 could reduce (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) enlarged liver size, lipid accumulation\/steatosis scores, and higher serum AST, ALT, \u03b3\u2010GT, triglyceride, and cholesterol levels induced by an alcoholic liquid diet. GBHP01\u2122 reduced liver inflammation and apoptosis in alcoholic liquid\u2010diet\u2010fed mice via decreasing TBARS, interleukin\u20106, interleukin\u20101\u03b2, and tumor necrosis factor\u2010\u03b1 levels, increasing reduced GSH\/TEAC levels and activities of SOD, CAT and GPx, as well as downregulating CYP2E1, BAX\/BCL2, Cleaved CASPASE\u20109\/Total CASPASE\u20109 and Active CASPASE\u20103\/Pro\u2010CASPASE\u20103 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). Furthermore, GBHP01\u2122 elevated hepatic alcohol metabolism (ADH and ALDH activities) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). In conclusion, this study prove the hepatoprotection of GBHP01\u2122 against alcohol consumption.\n                  <\/jats:p>","DOI":"10.1002\/tox.24072","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T07:46:18Z","timestamp":1701848778000},"page":"1759-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A functional chicken\u2010liver hydrolysate\u2010based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti\u2010inflammation, and antiapoptosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Yi\u2010Hsieng Samuel","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei City Taiwan"},{"name":"Institute of Food Safety and Health Risk Assessment National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei City Taiwan"},{"name":"Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Feng","family":"Kao","sequence":"additional","affiliation":[{"name":"Seafood Technology Division, Fisheries Research Institute Ministry of Agriculture  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jr\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Animal Industry Ministry of Agriculture  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chou","family":"Chen","sequence":"additional","affiliation":[{"name":"Great Billion Biotech Co., Limited.  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