{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:22:31Z","timestamp":1785943351412,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic nephropathy (DN) is one of the complications of diabetes mellitus and the main cause of end\u2010stage renal disease (ESRD), which is a serious threat to human health. In DN, mesangial cells (MCs) are a critical target cell that perform a variety of key functions, and abnormal proliferation of MCs is a common and prominent pathological change in DN. In recent years, the investigation of Chinese medicine interventions for DN has increased significantly in recent years due to the many potential adverse effects and controversies associated with the treatment of DN with Western medicines. In this study, we evaluated the protective effect of resveratrol (RES), an active ingredient known as a natural antioxidant, on HMCs under high glucose and explored its possible mechanism of action. We found that RES inhibited the proliferation of human mesangial cell (HMC) under high glucose and blocked cell cycle progression. In the high glucose environment, RES upregulated miR\u20101231, reduced IGF1 expression, inhibited the activity of the extracellular signal\u2010regulated kinase (ERK) signaling pathway and reduced levels of the inflammatory factors TNF\u2010\u03b1 and IL\u20106. In addition, we found that miR\u20101231 mimics were synergistically inhibited with RES, whereas miR\u20101231 inhibitor attenuated the protective effect of RES on HMCs. Thus, our results suggest that the protective effect of RES on HMCs under high glucose is achieved, at least in part, through modulation of the miR\u20101231\/IGF1\/ERK pathway. The discovery of this potential mechanism may provide a new molecular therapeutic target for the prevention and treatment of DN, and may also bring new ideas for the clinical research in DN.<\/jats:p>","DOI":"10.1002\/tox.24103","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T09:38:54Z","timestamp":1703842734000},"page":"2326-2339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Resveratrol protects mesangial cells under high glucose by regulating the <scp>miR<\/scp>\u20101231\/<scp>IGF1<\/scp>\/<scp>ERK<\/scp> pathway"],"prefix":"10.1002","volume":"39","author":[{"given":"Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy Jilin University  Changchun Jilin Province 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