{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:28:39Z","timestamp":1777710519961,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["11\u2010CX29"],"award-info":[{"award-number":["11\u2010CX29"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20220387"],"award-info":[{"award-number":["Y20220387"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Perfluorotetradecanoic acid (PFTeDA) is a novel perfluoroalkyl substance that ubiquitously exists in the environment. However, whether PFTeDA affects adrenal cortex function remains unclear. Male Sprague\u2013Dawley rats (age of 60\u2009days) were daily administered with PFTeDA (0, 1, 5, and 10\u2009mg\/kg body weight) through gavage for 28\u2009days. PFTeDA did not change body and adrenal gland weights. PFTeDA markedly elevated serum corticosterone level at 10\u2009mg\/kg but lowering serum aldosterone level at this dosage without influencing serum adrenocorticotropic hormone level. PFTeDA thickened zona fasciculata without affecting zona glomerulosa. PFTeDA remarkably upregulated the expression of corticosterone biosynthetic genes (\n                    <jats:italic>Mc2r, Scarb1<\/jats:italic>\n                    ,\n                    <jats:italic>Star<\/jats:italic>\n                    ,\n                    <jats:italic>Cyp21<\/jats:italic>\n                    ,\n                    <jats:italic>Cyp11b1,<\/jats:italic>\n                    and\n                    <jats:italic>Hsd11b1<\/jats:italic>\n                    ) and their proteins, whereas downregulating aldosterone biosynthetic enzyme\n                    <jats:italic>Cyp11b2<\/jats:italic>\n                    and its protein, thereby distinctly altering their serum levels. PFTeDA markedly downregulated the expression of antioxidant genes (\n                    <jats:italic>Sod1<\/jats:italic>\n                    and\n                    <jats:italic>Sod2<\/jats:italic>\n                    ) and their proteins at 10\u2009mg\/kg. PFTeDA significantly decreased SIRT1\/PGC1\u03b1 and AMPK signaling while stimulating AKT1\/mTOR signaling. Corticosterone significantly inhibited testosterone production by adult Leydig cells at &gt;0.1\u2009\u03bcM in vitro; however aldosterone significantly stimulated testosterone production at 0.1\u2009nM. In conclusion, exposure to PFTeDA at male rat adulthood causes corticosterone excess and aldosterone deficiency via SIRT1\/PGC1\u03b1, AMPK, and AKT1\/mTOR signals, which in turn additively leads to testosterone deficiency.\n                  <\/jats:p>","DOI":"10.1002\/tox.24135","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T04:39:48Z","timestamp":1704947988000},"page":"2610-2622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production"],"prefix":"10.1002","volume":"39","author":[{"given":"Yingfen","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 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