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This study examined the effects of maternal exposure to GlyP and GBH on rat cerebellar development in male offspring. From day 6 of gestation until day 21 postpartum at weaning, dams were given GlyP at 1.5% or 3.0% in diet or GBH at 1.0% in drinking water (corresponding to 0.36% GlyP). At weaning, GBH exposure was linked to increased numbers of DCX\n                    <jats:sup>+<\/jats:sup>\n                    migrating granule cells in the cortex and TUNEL\n                    <jats:sup>+<\/jats:sup>\n                    apoptotic cells in the internal granular layer (IGL), suggesting the disappearance of mismigrated granule cells via apoptosis. GBH also upregulated\n                    <jats:italic>Nr4a3<\/jats:italic>\n                    and downregulated\n                    <jats:italic>Cdk5<\/jats:italic>\n                    in the cerebellar vermis, suggesting a causal relation with the impaired granule cell development at this time. GlyP (3.0%) tended to increase in the number of DCX\n                    <jats:sup>+<\/jats:sup>\n                    migrating granule cells in the IGL and upregulated\n                    <jats:italic>Nr4a3<\/jats:italic>\n                    at weaning. Both compounds also upregulated genes related to granule cell migration (\n                    <jats:italic>Astn1<\/jats:italic>\n                    ,\n                    <jats:italic>Astn2<\/jats:italic>\n                    ,\n                    <jats:italic>Nfia<\/jats:italic>\n                    , and\/or\n                    <jats:italic>Nfix<\/jats:italic>\n                    ) at weaning and in adulthood, which might be an ameliorative response to delayed granule cell migration. Moreover, GBH induced Purkinje cell misalignment at weaning, which could be the result of delayed granule cell migration. In adulthood, GBH was associated with upregulation of the reelin signaling\u2010related genes\n                    <jats:italic>Reln<\/jats:italic>\n                    ,\n                    <jats:italic>Dab1<\/jats:italic>\n                    , and\n                    <jats:italic>Efnb1<\/jats:italic>\n                    , suggesting a compensatory response to Purkinje cell misalignment. GlyP induced the same gene expression changes. These results suggest that GBH reversibly disrupts cerebellar development, primarily by targeting granule cell migration and differentiation, whereas GlyP exhibited similar toxic potential as GBH.\n                  <\/jats:p>","DOI":"10.1002\/tox.24163","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:37:33Z","timestamp":1707273453000},"page":"3040-3054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Similar toxicity potential of glyphosate and glyphosate\u2010based herbicide on cerebellar development after maternal exposure in rats"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-5252","authenticated-orcid":false,"given":"Ryota","family":"Ojiro","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-5871","authenticated-orcid":false,"given":"Shunsuke","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zou","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gye\u2010Hyeong","family":"Woo","sequence":"additional","affiliation":[{"name":"Laboratory of Histopathology, Department of Clinical Laboratory Science Semyung University  Jecheon\u2010si Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-9697","authenticated-orcid":false,"given":"Makoto","family":"Shibutani","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology  Tokyo Japan"},{"name":"Institute of Global Innovation Research Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.08.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80888-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1999.1371"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2021.763917"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.11.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-018-9894-2"},{"key":"e_1_2_10_8_1","unstructured":"Organisation for Economic Co\u2010operation and Development (OECD).Test Guideline 426: Developmental Neurotoxicity Study. 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