{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:08:11Z","timestamp":1782122891428,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As no study about the combined effect of low levels of Cd\n                    <jats:sup>2+<\/jats:sup>\n                    with procymidone (PCM) on organs and organisms, we investigated their actions on mouse\u2010ovary in vivo and in vitro. Four\u2010week mice were treated with corn oil for the control group, corn oil\u2009+\u20090.0045\u2009mg\/L Cd\n                    <jats:sup>2+<\/jats:sup>\n                    (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    was dissolved in ultrapure water and freely consumed by mice) for Cd\n                    <jats:sup>2+<\/jats:sup>\n                    group, 50\u2009mg\/kg\/d PCM (suspended in corn oil and administered orally to mice) for PCM group, and 50\u2009mg\/kg\/d PCM\u2009+\u20090.0015 (0.0045 and 0.0135) mg\/L Cd\n                    <jats:sup>2+<\/jats:sup>\n                    for L+ (M+ and H+) PCM group for 21\u2009days. For in vitro experiment, the cultured ovaries were treated with acetone for the control group, 0.1% acetone\u2009+\u20098.4\u2009\u03bcg\/L Cd\n                    <jats:sup>2+<\/jats:sup>\n                    for the Cd\n                    <jats:sup>2+<\/jats:sup>\n                    group, 0.63\u2009mg\/L PCM (dissolved in acetone) for the PCM\u2010group, and 0.63\u2009mg\/L PCM\u2009+\u20092.8 (8.4 and 25.2) \u03bcg\/L Cd\n                    <jats:sup>2+<\/jats:sup>\n                    for L+ (M+ and H+) PCM group for 7\u2009days. Mouse body weight in each treatment group, the weight and volume of ovaries in all PCM groups were lower than the control. Both in vivo and in vitro, all\u2010stage follicle numbers were lower in M+PCM and H+PCM groups, whereas the atretic follicles and CASPASE3\/8 were higher; meanwhile, lower estradiol and progesterone and higher unfolded protein response (UPR) members in all PCM groups. L+, M+, and H+PCM groups had further ovarian damage and stronger UPR than PCM groups, as did M+PCM groups over Cd\n                    <jats:sup>2+<\/jats:sup>\n                    groups. It is hypothesized low\u2010level PCM and Cd\n                    <jats:sup>2+<\/jats:sup>\n                    may mutually promote each other's triggered UPR and exacerbate ovarian damage.\n                  <\/jats:p>","DOI":"10.1002\/tox.24169","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:42:36Z","timestamp":1707280956000},"page":"3160-3171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low levels of Cd\n                    <sup>2+<\/sup>\n                    combined with procymidone may cause ovarian damage in mice via unfolded protein response"],"prefix":"10.1002","volume":"39","author":[{"given":"Fan","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuning","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruowen","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-6445","authenticated-orcid":false,"given":"Yongfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Medical School Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy089"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.4282"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6774"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.113068"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.735622"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.04.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fow049"},{"key":"e_1_2_9_10_1","volume-title":"Sanitation Standards for Drinking Water (GB 5749\u20102006) [S]","author":"Ministry of Health of the People's Republic of China, China National Standardization Administration Committee","year":"2007"},{"key":"e_1_2_9_11_1","unstructured":"JMPR.Pesticide residues in food 2007[J]. 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