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This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT\u2010R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti\u2010inflammatory and anti\u2010oxidative capacities. Thus, EA has potential preventive effects on cardiovascular diseases and diabetes. In the last decades, because the protective effect of EA on Ang\u2010II\u2010induced hypertrophic responses is unclear, this study aims to investigate the protective effect of EA in cardiomyocytes. H9c2 cells were treated to Ang\u2010II 1\u2009\u03bcM for 24\u2009h to induce cellular damage. We found that EA protected against Ang\u2010II\u2010increased cell surface area and pro\u2010hypertrophic gene expression in H9c2. EA reduced Ang\u2010II\u2010caused AT\u2010R1 upregulation, thereby inhibiting oxidative stress NADPH oxidase activation. EA mitigated Ang\u2010II\u2010enhanced p38 and extracellular\u2010signal\u2010regulated kinase (ERK) phosphorylation. Moreover, EA treatment under Ang\u2010II stimulation also reversed NF\u2010\u03baB activity and iNOS expression. This study shows that EA protects against Ang\u2010II\u2010induced myocardial hypertrophy and attenuates oxidative stress through reactive oxygen species\u2010mediated mitogen\u2010activated protein kinase signaling pathways in H9c2 cells. Thus, EA may be an effective compound for preventing Ang\u2010II\u2010induced myocardial hypertrophy.<\/jats:p>","DOI":"10.1002\/tox.24170","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T03:39:25Z","timestamp":1707968365000},"page":"3253-3263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ellagic acid protects against angiotensin\n                    <scp>II<\/scp>\n                    \u2010induced hypertrophic responses through\n                    <scp>ROS<\/scp>\n                    \u2010mediated\n                    <scp>MAPK<\/scp>\n                    pathway in H9c2 cells"],"prefix":"10.1002","volume":"39","author":[{"given":"Ya\u2010Che","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Urology Ditmanson Medical Foundation Chiayi Christian Hospital  Chia\u2010Yi City 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