{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:50Z","timestamp":1786978610640,"version":"build-2736575974"},"reference-count":83,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous observational studies have linked circulating cytokines to sarcopenia, but their causal relationship remains unclear. This study employed Mendelian Randomization (MR) to investigate the causal links between circulating cytokines and sarcopenia\u2010related traits using genetic data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010sample bidirectional MR analysis was conducted using data from individuals of European ancestry, utilizing genome\u2010wide association studies (GWAS) statistics. The study selected instrumental single nucleotide polymorphisms (SNPs) significantly associated with circulating cytokines and applied multiple MR methods, including inverse variance weighted (IVW), Weighted Median, MR\u2010Egger, Weighted Mode, Simple Mode, and MR\u2010PRESSO. The traits analyzed were appendicular lean mass (ALM) and grip strength. Heterogeneity, robustness, and consistency of results were assessed using Cochran's Q statistic, MR\u2010Egger regression, and \u201cleave\u2010one\u2010out\u201d sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IVM\u2010MR analysis showed a casual association between genetically predicted circulating levels of interleukin\u201016 and both ALM and grip strength (ALM: OR\u2009=\u20090.990, 95% CI: 0.980\u20131.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.049; grip strength: OR\u2009=\u20090.971, 95% CI: 0.948\u20130.995,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.020). Additionally, interferon\u2010gamma\u2010induced protein 10 (IP\u201010), interleukin\u20101\u2010beta (IL\u20101\u03b2), and hepatocyte growth factor (HGF) were correlated with ALM and vascular endothelial growth factor (VEGF), interleukin\u201012 (IL\u201012), and interleukin\u20105 (IL\u20105) with grip strength. Comparable results were confirmed via the MR\u2010Egger, Weighted Median, Weighted Mode, and Simple Mode methods. Sensitivity analysis showed no horizontal pleiotropy to bias the causal estimates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results suggest a significant causal effect of inflammatory cytokines on sarcopenia, offering new avenues for therapeutic target development. However, the study's focus on a European ancestry cohort limits its generalizability to other populations. Future research should aim to include diverse ethnic groups to validate and broaden these findings, thereby enhancing our understanding of sarcopenia's mechanisms in a global context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/tox.24206","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T06:04:51Z","timestamp":1709791491000},"page":"3434-3447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the causal link between circulating cytokines and sarcopenia traits: A Mendelian randomization analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5538-9099","authenticated-orcid":false,"given":"Wang","family":"Di","sequence":"first","affiliation":[{"name":"Department of Sports Science, College of Education Zhejiang University  Hangzhou 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