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Yet, the capacity of GA to ameliorate the advance of HCC pertinent to nonalcoholic fatty liver disease (NAFLD) remains to be clarified. We used the CCK\u20108 method to detect the optimal treatment concentration and time for L\u201002 cells, palmitic acid (PA)\u2010induced L\u201002 cells and HepG2 cells, and selected 40\u2009\u03bcM and 48\u2009h to treat PA\u2010induced L\u201002 cells and 60\u2009\u03bcM for 24\u2009h to treat HepG2 cells. Moreover, functional associations of HepG2 cells were elucidated through various assays. The results showed that GA demonstrated enhances lipid deposition and alleviates the inflammatory response in L\u201002 cells induced by palmitic acid. Simultaneously, we found that GA inhibits the proliferation, migration, and invasion while promoting apoptosis in HepG2 cells. In pursuit of constructing of HCC model rats, a combination of high\u2010fat diets and diethylnitrosamine was utilized. The results showed that GA significantly decreased the liver index, body weight, liver weight, and the number of nodules in HCC model rats. Moreover, GA mitigated infiltration and heightened apoptosis in these rats. Mechanistically, GA notably attenuated the KK\u03b2\/NF\u2010\u03baB pathway in both HepG2 cells and the HCC model rats. In conclusion, GA functions as an inhibitor in the progression of NAFLD\u2010related HCC cells, which might be relevant to the KK\u03b2\/NF\u2010\u03baB pathway. Therefore, GA is a potential drug for NAFLD\u2010related HCC treatment.<\/jats:p>","DOI":"10.1002\/tox.24295","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:21:33Z","timestamp":1714728093000},"page":"4677-4688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glycyrrhizic acid attenuates the malignant biological properties of nonalcoholic fatty liver disease\u2010related hepatocellular carcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Xueqing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengwei","family":"You","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical University  Guiyang 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