{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:42:14Z","timestamp":1788583334763,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic Prostatitis\/Chronic Pelvic Pain Syndrome (CP\/CPPS) is a common and serious disease with unclear pathogenesis and recurrent symptoms. Hedyotis diffusa Willd (HDW) has been recognized for its potential in managing various chronic inflammatory diseases. This research aimed to interrogate the mechanism of HDW in treating CP\/CPPS. Complete Freund Adjuvant (CFA) and LPS were utilized to establish the rat and cell models of CP\/CPPS. Results showed that HDW decreased levels of inflammation\u2010related factors in CP rat prostate tissue and LPS\u2010elicited RWPE\u20101 cell injury model. Moreover, HDW administration impaired oxidative stress in the prostate and RWPE\u20101 cells. In addition, HDW treatment activated the NRF2\/ARE signaling in rat prostate tissue and cell models. Interestingly, NRF2\/ARE pathway inhibitor ML385 reversed the inhibition effects of cell apoptosis, inflammation, and oxidative stress triggered by HDW. In summary, HDW alleviated inflammation and oxidative stress by activating NRF2\/ARE signaling in CP\/CPPS rat model and human prostate epithelial cell injury model.<\/jats:p>","DOI":"10.1002\/tox.24298","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:35:12Z","timestamp":1715585712000},"page":"4221-4230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the\n                    <scp>NRF2<\/scp>\n                    \/\n                    <scp>ARE<\/scp>\n                    signaling pathway"],"prefix":"10.1002","volume":"39","author":[{"given":"Junfu","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Urology, Chongqing Hospital the First Affiliated Hospital of Guangzhou University of Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology, Chongqing Hospital the First Affiliated Hospital of Guangzhou University of Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0897-3433","authenticated-orcid":false,"given":"Chaokui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Chongqing Hospital the First Affiliated Hospital of Guangzhou University of Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0237-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1620203"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.128"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02161-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.1.122"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00898"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.12.32"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA06608K"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1753"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7802639"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115597"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2963"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13913"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.055"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155440"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.08.020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.061"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28380"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28608"},{"issue":"6","key":"e_1_2_8_23_1","first-page":"8197","article-title":"Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways","volume":"14","author":"Feng J","year":"2017","journal-title":"Oncol Lett"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.3.391"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.04.066"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.11.071"},{"issue":"5","key":"e_1_2_8_27_1","first-page":"532","article-title":"Hedyotis diffusa Willd extract protects rat renal tubular epithelial cells from high glucose\u2010induced injury by inhibiting PI3K\/AKT signaling pathway. 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