{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:07:53Z","timestamp":1774015673927,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["103\u20102313\u2010B\u2010040\u2010003\u2010MY3"],"award-info":[{"award-number":["103\u20102313\u2010B\u2010040\u2010003\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gossypol, a natural polyphenolic compound, possesses antivirus activity and induces cell death of different types of tumors. However, the efficacy of gossypol on lung carcinoma metastases and epithelial to mesenchymal transition remains unknown. The aim of the present work was to determine the cellular and molecular mechanism of the anti\u2010cancer and anti\u2010metastatic efficacies of gossypol on human lung carcinoma cells. Gossypol showed a marked suppression of the viability, motility, and invasion in H1299 and A549 cells. Zymography assay showed that gossypol was sufficient to suppress the activities of urokinase\u2010type plasminogen activator and matrix metalloproteinase\u20102. Gossypol reversed TGF\u2010\u03b2\u2010induced epithelial to mesenchymal transition. Gossypol reduced vimentin, p\u2010FAK, p\u2010Src and p\u2010paxillin. In vivo studies of gossypol were performed using subcutaneous inoculation and tail vein injection of A549 into immunodeficient BALB\/c nude mice and severe combined immunodeficient mice.<\/jats:p>","DOI":"10.1002\/tox.24363","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T08:50:35Z","timestamp":1726131035000},"page":"5209-5221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gossypol Inhibits Metastasis of Lung Cell Carcinoma by Reversing Epithelial to Mesenchymal Transition and Suppressing Proteases Activity"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-8853","authenticated-orcid":false,"given":"Yih\u2010Shou","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Han","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Chen","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute and Department of Food Science Central Taiwan University of Sciences and Technology  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-8719","authenticated-orcid":false,"given":"Pei\u2010Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.18.8047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145567"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-220222"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2023.100137"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1880"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/27697061.2022.2147106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101621"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.02.044"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6804"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.02.036"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100595"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15040438"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115767"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23481"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23316"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22411"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22822"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1121"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199810000-00002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000215"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0296-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24181"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26185"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00531-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3792"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10529"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.09.006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1947-9"},{"issue":"6","key":"e_1_2_8_32_1","first-page":"2379","article-title":"Characterisation of Mesenchymal Colon Tumour\u2010Derived Cells in Tumourspheres as a Model for Colorectal Cancer Progression","volume":"53","author":"Turano M.","year":"2018","journal-title":"International Journal of Oncology"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.10.004"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06372-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67325-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080886"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.24363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:29:43Z","timestamp":1762594183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.24363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/tox.24363"],"URL":"https:\/\/doi.org\/10.1002\/tox.24363","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"2024-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}