{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:10Z","timestamp":1790268730128,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aluminum oxide nanoparticles (Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs) are among the most extensively utilized nanoparticles in nanotechnology and that have negative impacts on the environment. Therefore, the intention of this work is to investigate the protective and therapeutic effects of curcumin in nanoform\n                    <jats:bold>(<\/jats:bold>\n                    Cur NPs) against Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs induced kidney toxicity, oxidative stress, DNA damage, and changes in necrosis factor alpha (TNF\u03b1) and proliferating cell nuclear antigen (PCNA) expressions in male rats. Fifty healthy adult male were divided into five groups [G1, control; G2, received 50\u2009mg\/kg\/day for 4\u2009weeks of Cur NPs orally; G3, received 6\u2009mg\/kg BW orally for 4\u2009weeks of Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs; G4, (Cur NPs\u2009+\u2009Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs) received Cur NPs and Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs at a dose similar to G2 and G3, respectively for 4\u2009weeks; G5, (Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs\u2009+\u2009Cur NPs) received Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs at a dose similar to G3 for 4\u2009weeks then received Cur NPs at a dose similar to G2 for another 4\u2009weeks]. Current results revealed that Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs induced a significant elevation in serum urea, creatinine, chloride, calcium, kidney malondialdehyde (MDA), DNA damage, injury, TNF\u03b1 and PCNA expressions and a significant depletion in serum potassium, kidney superoxide dismutase (SOD), glutathione (GSH) as compared to control. On the other hand, treatments of Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs with Cur NPs induced modulation in all altered parameters and improved kidney functions and structure, with best results for the Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs\u2009+\u2009Cur NPs than Cur NPs\u2009+\u2009Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs. In conclusion, Cur NPs has the capacity to mitigate the renal toxicity induced by Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs in male albino rats.\n                  <\/jats:p>","DOI":"10.1002\/tox.24392","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T05:29:28Z","timestamp":1722922168000},"page":"5140-5149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ameliorating and Therapeutic Impact of Curcumin Nanoparticles Against Aluminum Oxide Nanoparticles Induced Kidney Toxicity,\n                    <scp>DNA<\/scp>\n                    Damage, Oxidative Stress,\n                    <scp>PCNA<\/scp>\n                    and\n                    <scp>TNF\u03b1<\/scp>\n                    Alteration in Male Rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Ehab","family":"Tousson","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim E. T.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Menoufia University  Shebin EI\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebatalla Nashaat","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Menoufia University  Shebin EI\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1408","authenticated-orcid":false,"given":"Amira S.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Hormones Department Medical Research and Clinical Studies Institute, National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"337","article-title":"Potential Therapeutic Effects of Avenanthramide\u2010C Against Lung Toxicity Caused by Silver Nanoparticles Injection in Rats","volume":"34","author":"Altwaijry N.","year":"2021","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"issue":"131","key":"e_1_2_9_3_1","first-page":"1487","article-title":"Beneficial Roles of Quercetin Nanoparticles Extracted From Euphorbia helioscopia Against Lung Damage in Mice","volume":"65","author":"Izzularab B. 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