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However, the approach to alleviation of T\u20102 toxin\u2010triggered hepatotoxicity has been recognized as a serious challenge. Resveratrol (Res) is a polyphenol natural product isolated from various plant species, but its protective effect against T\u20102 toxin hepatotoxicity and detailed mechanism remains obscure. In the present study, the effect of Res against the hepatotoxicity was evaluated, and the underlying mechanisms were further revealed in mice. Functionally, Res inhibited liver injury, oxidative damage, and mitochondrial dysfunction induced by T\u20102 toxin. Mechanistically, Res modulated Nrf2\u2010mediated antioxidant pathway and glutathione synthesis inhibition. Collectively, our findings first showed beyond doubt that Res ameliorated T\u20102 toxin\u2010triggered liver injury by regulating Nrf2 pathways in mice.<\/jats:p>","DOI":"10.1002\/tox.24412","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T10:05:48Z","timestamp":1725357948000},"page":"19-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Resveratrol Alleviated T\u20102 Toxin\u2010Induced Liver Injury via Preservation of Nrf2 Pathway and <scp>GSH<\/scp> Synthesis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1582-9351","authenticated-orcid":false,"given":"Hong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Military Operation Medical Protection Chinese PLA Center for Disease Control and Prevention  Beijing Fengtai District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Military Operation Medical Protection Chinese PLA Center for Disease Control and Prevention  Beijing Fengtai District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health China Medical University  Shenyang Shenbei New District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health China Medical University  Shenyang Shenbei New District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Military Operation Medical Protection Chinese PLA Center for Disease Control and Prevention  Beijing Fengtai District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Military Operation Medical Protection Chinese PLA Center for Disease Control and Prevention  Beijing Fengtai District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Military Operation Medical Protection Chinese PLA Center for Disease Control and Prevention  Beijing Fengtai District China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.121784"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26226868"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113392"},{"key":"e_1_2_11_5_1","first-page":"851","article-title":"Comparison of T\u20102 Toxin and HT\u20102 Toxin Distributed in the Skeletal System With That in Other Tissues of Rats by Acute Toxicity Test","volume":"30","author":"Yu F. 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