{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T08:40:42Z","timestamp":1736844042835,"version":"3.33.0"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Plantain has been reported to enhance testicular function indices, however, the mechanism remains unknown. The present study investigated the action mechanisms of a plantain\u2010based diet in the treatment of rat testicular dysfunction caused by exposure to atrazine (ATZ). The rats were grouped into 10 groups (5 rats each); control group, 50% plantain\u2010based diet (50% PBD), 25% PBD, 12.5% PBD, quercetin (QUE), ATZ only, 50% PBD\u2009+\u2009ATZ, 25% PBD\u2009+\u2009ATZ, 12.5% PBD\u2009+\u2009ATZ, and QUE\u2009+\u2009ATZ for 21\u2009days. Results revealed that ATZ treatments in rats lowered gonadal hormone levels and the semen quality (sperm concentration, motility, count, and viability), damaged testicular morphology and functions, and impaired redox\u2010inflammatory balance as well as cholinergic and purinergic activities. However, treatment with PBD and QUE ameliorated the testicular toxicity induced by ATZ, although the treatment did not improve the rat semen quality. In addition, the ATZ\u2009+\u2009QUE and QUE groups showed mild to moderate atrophic degenerative changes, with reduced spermatogenic activity. Together, the results are evidence that 21\u2009days of exposure to ATZ impaired testicular function. However, co\u2010administration of atrazine and PBD improves rat gonadal hormones, redox state, inflammatory indices, cholinergic, and purinergic activities, as well as histoarchitecture of the testes.<\/jats:p>","DOI":"10.1002\/tox.24431","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T11:30:02Z","timestamp":1732102202000},"page":"291-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010Administration of a Plantain\u2010Based Diet and Quercetin Modulates Atrazine\u2010Induced Testicular Dysfunction in Rats via Testicular Steroidogenesis and Redox\u2010Inflammatory Processes"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-8065","authenticated-orcid":false,"given":"Damilare Emmanuel","family":"Rotimi","sequence":"first","affiliation":[{"name":"SDG 03 Group\u2014Good Health &amp; Well\u2010Being Landmark University  Omu\u2010Aran Nigeria"},{"name":"Department of Biochemistry Landmark University  Omu\u2010Aran Nigeria"},{"name":"Department of Pharmacology and Pharmaceutical Sciences Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California  Los Angeles, CA United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusola Olalekan","family":"Elekofehinti","sequence":"additional","affiliation":[{"name":"Bioinformatics and Molecular Biology Unit, Department of Biochemistry Federal University of Technology Akure  Ondo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olarewaju Michael","family":"Oluba","sequence":"additional","affiliation":[{"name":"SDG 03 Group\u2014Good Health &amp; Well\u2010Being Landmark University  Omu\u2010Aran Nigeria"},{"name":"Department of Biochemistry Landmark University  Omu\u2010Aran Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluyomi Stephen","family":"Adeyemi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medicinal Biochemistry, Nanomedicine &amp; Toxicology Laboratory Bowen University  Iwo Osun State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-23633-5_3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00178"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067319.2019.1597866"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-019-01800-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1139\/A09-009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2013.02.018"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134868"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.08.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909519107"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2005.00620.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6417"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00005.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.04.025"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2465-1"},{"issue":"2","key":"e_1_2_11_16_1","first-page":"75","article-title":"Functional and Pasting Properties of Wheat\/Plantain Flours Enriched With Bambara Groundnut Protein Concentrate","volume":"5","author":"Kiin\u2010Kabari D.","year":"2015","journal-title":"International Journal of Food Science and Nutrition Engineering"},{"issue":"1","key":"e_1_2_11_17_1","first-page":"123","article-title":"Phenolic Extracts of \u2018Amala\u2019 from Unripe Plantain (Musa Paradisiaca) Pulps Inhibit Key Enzymes Linked to Type\u20102\u2010Diabetes and Hypertension","volume":"9","author":"Shodehinde S.","year":"2013","journal-title":"FUTA Journal of Research in Sciences"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"105","article-title":"Effects of Unripe Musa Paradisiaca on the Histochemistry of the Testis and Testosterone Levels in Adult Albino Rats","volume":"32","author":"Alabi A.","year":"2017","journal-title":"Nigerian Journal of Physiological Sciences"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.20959\/wjpr20176-8579"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01064.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2022.07.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-04276-1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.11.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2012.06.004"},{"key":"e_1_2_11_25_1","unstructured":"National\u2010Research\u2010Council \u201cGuide for the Care and Use of Laboratory Animals \u201d (2011)."},{"issue":"4","key":"e_1_2_11_26_1","first-page":"290","article-title":"Production and Characterization of Unripe Plantain (Musa Paradisiaca l.) 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