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This study explored the ameliorative effects of <jats:italic>Ophiocordyceps sinensis<\/jats:italic> mycelia (TCM\u2010NA01 formula: 1.4\u2009mg adenosine and 55.2\u2009mg polysaccharide\/capsule) on hepatosteatosis development in a high\u2010fat diet (HFD)\u2010fed mice. TCM\u2010NA01 supplementation significantly reduced (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) body weight, adipose tissue, serum triglyceride (TG)\/cholesterol (TC), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), liver TG\/TC levels in HFD\u2010fed mice. Increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) fecal\u2010lipid and bile\u2010acid outputs were observed. Apparent reductions in lipid\u2010droplet and steatosis scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the HFD\u2010fed mice supplemented with TCM\u2010NA01. Furthermore, TCM\u2010NA01 modulated lipid metabolism by decreasing fatty acid synthesis and promoting fatty acid \u03b2\u2010oxidation. TCM\u2010NA01 also enhanced liver antioxidant capacity and decreased proinflammatory cytokines (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These findings underscore the potential of <jats:italic>O.\u2009sinensis<\/jats:italic> mycelia as a nutraceutical agent for alleviating hepatosteatosis, liver oxidative stress, and chronic inflammation, offering a promising strategy for the management of obesity and NAFLD.<\/jats:p>","DOI":"10.1002\/tox.24499","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:18:36Z","timestamp":1740111516000},"page":"1034-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Modulatory Effects of <i>Ophiocordyceps sinensis<\/i> Mycelia on Hepatosteatosis Development in a High\u2010Fat Dietary Habit"],"prefix":"10.1002","volume":"40","author":[{"given":"Yi\u2010Ling","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei City Taiwan"},{"name":"Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoper Caesar Yudho","family":"Sutopo","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Feng","family":"Kao","sequence":"additional","affiliation":[{"name":"Seafood Technology Division Fisheries Research Institute, Ministry of Agriculture  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Kai","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Optometry Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-2115","authenticated-orcid":false,"given":"Yi\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei City Taiwan"},{"name":"Master Program in Global Agriculture Technology and Genomic Science, International College National Taiwan University  Taipei City 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