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Endocrine disruptors chemicals (EDCs), an important component of such exposures, exert adverse effects on human health. The kidneys are targets for EDCs because of their characteristic of bioaccumulation. Therefore, we aimed to evaluate cellular and tissue changes in the kidneys of rats exposed to an EDCs mixture (EDCs Mix). Pregnant female Sprague\u2013Dawley rats were divided into: Control group, administered vehicle (corn oil) via gavage; EDCs mix group, administered 32.11\u2009mg\/kg\/day of a mixture of 12 EDCs diluted in corn oil (2\u2009mL\/kg) via gavage. Pregnant or lactating rats received the treatment from Gestational Day 7 until Postnatal Day (DPN) 21. The male pups continued to receive the complete EDCs mix until DPN220, when they were euthanized. Nuclear alterations depended on the compartment evaluated, with the EDCs mix favoring the presence of elliptical nuclei in the cortical and glomerular regions and more rounded nuclei in the medullary region. The EDCs mix increased renal fibrosis in all compartments without altering antioxidant enzymes activity. Therefore, we conclude that environmentally relevant exposure to an EDCs mix causes nuclear changes and induces renal fibrosis.<\/jats:p>","DOI":"10.1002\/tox.24502","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:42:15Z","timestamp":1741686135000},"page":"1087-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Exposure to an Environmentally Relevant Mixture of Endocrine Disruptors Alters Nuclear Phenotype and Induces Renal Fibrosis in Rats"],"prefix":"10.1002","volume":"40","author":[{"given":"Karianne Delalibera","family":"Hinokuma","sequence":"first","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza Silva","family":"Ricardo","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia Yuri","family":"Yoshigae","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaina Cavalleri","family":"Sousa","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Pereira","family":"de Souza","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Alborghetti","family":"Nai","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"},{"name":"Master Program in Health Science Western S\u00e3o Paulo University (UNOESTE), Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaura Scantamburlo Alves","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of General Biology, Biological Sciences Center State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana Regina","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of General Biology, Biological Sciences Center State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Rentz Ferreira","family":"Laginski","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard and Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9761-7653","authenticated-orcid":false,"given":"Leonardo","family":"de Oliveira Mendes","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Western S\u00e3o Paulo University (UNOESTE) Rodovia Raposo Tavares  Brazil"},{"name":"Master Program in Health Science Western S\u00e3o Paulo University (UNOESTE), Rodovia Raposo Tavares  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201005\u20100456"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft251"},{"key":"e_1_2_11_4_1","unstructured":"\u00c5.Bergman J. 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