{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:51:32Z","timestamp":1787507492748,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["IF190470"],"award-info":[{"award-number":["IF190470"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Exposure to acrylamide (AA) through food is nearly unavoidable and can lead to long\u2010lasting consequences. AA has been shown to cause reproductive toxicity and reduce ovarian weight and follicle number when taken orally. Flavonoids derived from plants are bioactive compounds that are increasingly being used in medicine. In this research, we aimed to investigate the ability of hesperidin (HES), a bioactive compound derived from plants, in shielding rats from AA\u2010induced ovarian damage. We identified possible target genes related to HES therapy and AA toxicity and conducted functional enrichment and pathway analysis to understand their biological significance. Additionally, we performed molecular docking of the core target gene with AA and HES. During the animal experimentation, rats were first exposed to 40\u2009mg\/kg of AA orally for 10\u2009days and then received HES therapy at various doses for three consecutive days. All animals were euthanised 24\u2009h after receiving the final treatment. We evaluated reproductive hormones, oxidative stress markers, membrane\u2010bound enzymes, glycogen content, and histological findings to determine the protective efficacy of HES. The study found that HES has a high binding affinity with the core target proteins and showed impressive protection against oxidative damage induced by AA in our in\u00a0vivo experiment. This protection can likely be attributed to HES's potent antioxidant properties.<\/jats:p>","DOI":"10.1002\/tox.24577","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:50:30Z","timestamp":1760701830000},"page":"315-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hesperidin Attenuates Acrylamide\u2010Induced Ovarian Toxicity in Rats: Based on Network Pharmacology, Molecular Docking, and In\u00a0Vivo Studies"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-4561","authenticated-orcid":false,"given":"Divya","family":"Gupta","sequence":"first","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University  Gwalior India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University  Gwalior India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-7719","authenticated-orcid":false,"given":"Chakresh Kumar","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Jaypee Institute of Information Technology  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Jaypee Institute of Information Technology  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, School of Allied Health Sciences and Management Delhi Pharmaceutical Sciences and Research University  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5814-8337","authenticated-orcid":false,"given":"Sangeeta","family":"Shukla","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University  Gwalior India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsh3.12020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6258508"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.APJR.2015.05.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201019\u20101628"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES27092665"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ETP.2017.05.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569543.2018.1474926"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JPROTEOME.8B00702"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/GB\u20102003\u20104\u20109\u2010R60"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2023.116736"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCC.21334"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1471\u20104159.1968.TB06187.X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(76)90323\u20107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(19)45228\u20109"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-016874-6.50044-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.2042\u20107158.1966.TB07822.X"},{"key":"e_1_2_10_18_1","first-page":"191","article-title":"The Estimation of Glycogen With the Anthrone Reagent","volume":"25","author":"Seifter S.","year":"1950","journal-title":"Archives of Biochemistry"},{"key":"e_1_2_10_19_1","volume-title":"Statistical Methods: Applied to Experiments in Agriculture and Biology","author":"Snedecor G.","year":"1956"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfab125"},{"key":"e_1_2_10_21_1","volume-title":"Rapid Screening of Acrylamide in French Fries Using Handheld and Portable Vibrational Spectroscopy","author":"Ren L.","year":"2019"},{"key":"e_1_2_10_22_1","volume-title":"Acrylamide Contamination in Commercial Potato Crisps in Kenya: Levels of Intake and Effects of Processing Parameters in Local Cultivars","author":"Ogolla J. 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