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A bibliometric analysis was conducted using the Web of Science\u2010Core Collection, extracting data such as citation count, authors, keywords, journal, publication year, country, and continent. After reviewing the studies, additional information\u2014including study design, investigated organs and tissues, main outcomes, and fluoride levels\u2014was obtained. The initial search retrieved 5983 articles, from which the 100 most\u2010cited were selected, totaling 16\u2009813 citations. The journal Fluoride published the highest number of articles (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), with keywords like \u201cfluoride,\u201d \u201cfluorosis,\u201d \u201cdental fluorosis,\u201d and \u201coxidative stress\u201d being the most prevalent. India and China accounted for the largest share of publications. The most common study types were observational studies, literature reviews, and in\u00a0vitro studies. Several studies reported fluoride's effects on dental and skeletal fluorosis, as well as damage to the brain, thyroid, gastrointestinal tract, heart, liver, kidneys, and specific cell types. This study highlights significant concerns regarding excessive fluoride exposure and identifies key research trends and gaps, particularly in the understanding of molecular mechanisms underlying fluoride\u2010induced damage.\n                  <\/jats:p>","DOI":"10.1002\/tox.24600","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:16:12Z","timestamp":1763381772000},"page":"416-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-8770","authenticated-orcid":false,"given":"Maria Karolina Martins","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Oliveira","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-1987","authenticated-orcid":false,"given":"Fatemeh Vida","family":"Zohoori","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Teesside University  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza Angeles","family":"Martinez\u2010Mier","sequence":"additional","affiliation":[{"name":"Department of Dental Public Health and Dental Informatics Indiana University School of Dentistry  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Afonso Rabelo","family":"Buzalaf","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4013","authenticated-orcid":false,"given":"Rafael Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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