{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:18:42Z","timestamp":1783473522035,"version":"3.55.0"},"reference-count":102,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aims to investigate the biochemical and histological impacts of pesticide exposure on the sandfish skink,\n                    <jats:italic>Scincus scincus<\/jats:italic>\n                    , in the agricultural region of El Oued\u2010Souf, Algeria. We carried out biochemical blood analysis and histological examination on lizards sampled from sites with high, moderate, and low exposure to pesticides. Biochemical analyses revealed\u00a0significant disturbances in glucose and lipid metabolism, renal function, and systemic inflammation, correlating\u00a0with varying levels of exposure to pesticides. The high\u2010exposure group exhibited marked hyperglycemia (2.06\u2009\u00b1\u20090.29\u2009mmol\/L), elevated cholesterol (1.99\u2009\u00b1\u20090.44\u2009mmol\/L), and triglycerides (1.28\u2009\u00b1\u20090.42\u2009mmol\/L), along with significant increases in C\u2010reactive protein levels (11.78\u2009\u00b1\u20099.4), indicating systemic inflammation. Histological examination of heart, liver, and stomach tissues revealed a clear, exposure\u2010gradient\u2010dependent spectrum of pathological alterations. In samples from high\u2010exposure sites, tissues exhibited prominent interstitial fibrosis, marked infiltration of inflammatory cells, and a pronounced disruption of normal cellular architecture. These findings provide compelling evidence that increasing levels of pesticide exposure in agricultural areas are linked not only to systemic biochemical disturbances but also to significant local tissue damage in\n                    <jats:italic>Scincus scincus<\/jats:italic>\n                    , thus underlining the broader ecological and public health risks associated with intensive pesticide use.\n                  <\/jats:p>","DOI":"10.1002\/tox.70004","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:43:31Z","timestamp":1764247411000},"page":"489-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pesticide Exposure on the Metabolic and Tissue Health of\n                    <scp>\n                      <i>Scincus scincus<\/i>\n                    <\/scp>\n                    (Reptilia: Scincidae) in Southeastern Algeria"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-132X","authenticated-orcid":false,"given":"Aicha","family":"Mouane","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Natural and Life Sciences University of EL Oued  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chikha","sequence":"additional","affiliation":[{"name":"Laboratory of Science and Techniques for Living Mohamed Cherif Messaadia University, Institute of Agricultural and Veterinary Sciences  Souk Ahras Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares Mohamed","family":"Amine","sequence":"additional","affiliation":[{"name":"Saharan Area Laboratory for Agricultural Modernization and Advancement (SALAMA \u2010 LAB) Higher School of Saharan Agriculture\u2014El Oued  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadra 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