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This study measured the ability of curcumin, an antioxidant, and curcumin Nano lipid carriers (Cur\u2010NLCs) to alleviate biochemical biomarkers of AA\u2010induced neurotoxicity in the cortex and hippocampus of exposed rats. Thirty adult female albino rats were assigned into one of five experimental groups: (1) negative control, (2) vehicle control, (3) acrylamide (50\u2009mg\/kg b.wt), (4) acrylamide (50\u2009mg\/kg b.wt) with curcumin (100\u2009mg\/kg b.wt), and (5) acrylamide (50\u2009mg\/kg b.wt) with Cur\u2010NLCs (10\u2009mg\/kg b.wt). Treatments were orally administered to rats for 5\u2009days\/week for 2\u2009weeks. Acrylamide administration caused body weight loss, abnormal gait, and histopathological damage to both the cortex and hippocampus. Curcumin and Cur\u2010NLCs treatment reduced the occurrence of abnormal behavior and mitigated histopathological changes observed in rats treated with AA. The level of norepinephrine (NE), dopamine (DA), gamma\u2010aminobutyric acid (GABA), serotonin (5\u2010HT), reduced glutathione (GSH), and adenosine triphosphate (ATP) were all decreased with AA treatment. Following treatment with curcumin, AA\u2010induced reductions in glutathione (GSH), dopamine (DA), 5\u2010hydroxy indole acetic acid (5\u2010HIAA), norepinephrine (NE), adenosine monophosphate (AMP), aspartate (ASP), and gamma\u2010aminobutyric acid were restored to the control level in the cortex. In the hippocampus, GSH, 8\u2010hydroxydeoxyguanosine (8\u2010OHdG), DA, 5\u2010hydroxy tryptamine (5\u2010HT), 5\u2010HIAA, NE, ATP, ASP, GABA and glutamate (Glu) improved to that observed in control rats. Co\u2010treatment with Cur\u2010NLCs also had protective effects on malondialdehyde (MDA) and NE in the cortex, and 5\u2010HIAA and ASP in the hippocampus. Upon comparison, Cur\u2010NLCs at 10\u2009mg\/kg\/day showed less benefit than curcumin alone (100\u2009mg\/kg\/day) based on several endpoints of oxidative stress, DNA damage, and histopathology. We conclude there are tissue specific responses to these formulations in the CNS and suggest that a more effective means of treating AA\u2010induced neurotoxicity with these antioxidants may be a mixture of both unmodified curcumin and its Nano\u2010formulation.<\/jats:p>","DOI":"10.1002\/tox.70043","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:59:11Z","timestamp":1770206351000},"page":"1011-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acrylamide\u2010Induced Neurotoxicity Is Mitigated by Curcumin and Its Nano Lipid Carrier Formulation in Albino Rats"],"prefix":"10.1002","volume":"41","author":[{"given":"Lobna A.","family":"Hassanin","sequence":"first","affiliation":[{"name":"Hormonal Evaluation Department Egyptian Drug Authority, EDA, Formerly NODCAR  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa 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