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However, evidence suggests that MPs and their chemical additives interfere with thyroid hormone signaling, adipocyte differentiation, and adipokine secretion. The mechanistic link across the thyroid\u2013adipose axis remains poorly defined. This review delves into cutting\u2010edge diagnostic technologies that are improving the identification, mapping, and understanding of MP\u2010induced endocrine and metabolic issues. Quantum\u2010dot nanosensors, single\u2010cell multiomics, machine learning\u2010assisted endocrine profiling, and microfluidic organ\u2010on\u2010chip systems offer high\u2010resolution insights into how MPs interact with thyroid follicular cells and adipose tissues. These platforms, which combine environmental analysis and endocrine testing, enable the measurement of MP levels, the detection of hormone\u2010receptor changes, and the modeling of endocrine system disruptions, facilitating the early identification of imbalances, novel treatments, and monitoring strategies. This review affirms the importance of studying thyroid toxicity with a focus on the adipose axis, emphasizing the importance of developing advanced diagnostic tools to assess metabolic risk in contaminated populations.<\/jats:p>","DOI":"10.1002\/tox.70129","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:45:14Z","timestamp":1779705914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microplastics and the Endocrine\u2013Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid\u2013Adipose Axis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-3301","authenticated-orcid":false,"given":"Sunday Amos","family":"Onikanni","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Endocrinology\u2013LEEx, Health Sciences Center Institute of Biomedical Sciences, Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Graduate Program in Pharmacology and Medicinal Chemistry, Health Sciences Center Institute of Biomedical Sciences, Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Department of Chemical Sciences, Biochemistry Unit Afe\u2010Babalola University  Ado\u2010Ekiti Ekiti State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babasola","family":"Aiyeku","sequence":"additional","affiliation":[{"name":"Northern Lincolnshire &amp; 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