{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:43:15Z","timestamp":1787506995780,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nanoceria or cerium oxide nanoparticles (CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) is extensively utilized in numerous sectors, such as electronics, environmental protection, pharmaceutical delivery systems, medical equipment, biotechnology, and the production of food and cosmetic products. This experiment planned to assess the possible toxic impacts and health hazards of nanoceria on major organs including the spleen, liver, kidneys, and lungs of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mus musculus<\/jats:italic>\n                    <\/jats:styled-content>\n                    through biochemical evaluations, gene expression analysis and histopathological examination. Fifteen male mice were randomly allocated into three equal groups: group C functioned as the untreated control and was kept under routine laboratory husbandry conditions with ad\u00a0libitum access to feed and water, without undergoing any treatment, administration, or additional handling procedures, group NC\u2010i.p received nanoceria at a dose of 40\u2009mg\/kg body weight via i.p injection twice weekly for 21\u2009days, and group NC\u2010i.n received nanoceria administered i.n (dropwise into the nostrils using a micropipette) at the same dose and schedule. After 21\u2009days, blood samples were collected for biochemical assessments, in addition to tissue samples from liver, kidney, lung, heart, and spleen for oxidative stress biomarkers, gene expression and histopathological examination. Our results revealed that nanoceria caused significant hypoproteinemia, hypoalbuminemia, hypercholesterolemia, hypertriglyceridemia, and increased creatinine levels. Moreover, malondialdehyde (MDA) level was elevated, whereas glutathione (GSH) and glutathione perpxidase (GSPx) levels were reduced, along with a pronounced upregulation of\n                    <jats:italic>ERK1, JNK,<\/jats:italic>\n                    and\n                    <jats:italic>MAPKP38<\/jats:italic>\n                    gene expression in liver, kidney, lung, and spleen tissues. These findings highlight the potential toxicological hazards associated with nanoceria exposure.\n                  <\/jats:p>","DOI":"10.1002\/tox.70147","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:28:19Z","timestamp":1782937699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanoceria Provokes Apoptosis in Different Critical Organs of\n                    <i>Mus musculus<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-7822","authenticated-orcid":false,"given":"Hanan E.","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Veterinary Medicine Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman I.","family":"Hassanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam G.","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine Beni\u2010Suef University  Beni\u2010Suef 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