{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:27:36Z","timestamp":1787660856123,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Paraquat (PQ) is a globally and widely used high\u2010residue herbicide, also regarded as a potential environmental risk factor for neurodegenerative diseases (NDs). However, how PQ exerts neurotoxicity remains a mystery. The blood\u2013brain barrier (BBB) plays a crucial role in communicating between the central nervous system (CNS) and the peripheral blood. In this article, the core genes, which were mainly based on the potential targets for PQ, MPTP, and Diquat chemicals from the CTD database, intersected with the potential targets related to the symptoms of NDs from databases GeneCards and OMIM. Then GO and KEGG enrichments revealed IL\u201017A was involved. After being treated with PQ, in\u00a0vivo, C57BL\/6J mice showed low mood and decreased learning and memory abilities. Pathologically, there were captured CD3 and its CD4\/8 subsets, as well as IL\u201017A. Surprisingly, T cells in peripheral blood and spleen that responded to PQ gradually leaned towards Th17 cells and secreted IL\u201017A. Therefore, it is highly suspected that IL\u201017A plays a role in disrupting the BBB. In\u00a0vitro, constructed with recombinant IL\u201017A, and single\u2010PQ or mixtures (recombinant IL\u201017A and PQ) to\n                    <jats:italic>bEnd.3<\/jats:italic>\n                    cells, which together showed that IL\u201017A is a helper for PQ to aggravately disrupt the BBB. In\u00a0vivo, mice were treated with IL\u201017A neutralizing antibodies, which effectively inhibited the permeability damage of the BBB. And in the brain parenchyma, the expression of IL\u201017A also decreased. In summary, the first to respond to PQ were T cells in the peripheral blood, mainly secreting IL\u201017A, which also acted as a risk factor disrupting the BBB and assists PQ and other factors in infiltrating parenchyma.\n                  <\/jats:p>","DOI":"10.1002\/tox.70180","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:13:18Z","timestamp":1787659998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Mechanism of Paraquat\u2010Induced Blood\u2013Brain Barrier Disruption:\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>17A<\/scp>\n                    as a Risk Accelerator for Disrupting\n                    <scp>bEnd<\/scp>\n                    .3 Cells Tight Junction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5941-525X","authenticated-orcid":false,"given":"Ge","family":"Shi","sequence":"first","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2905-8992","authenticated-orcid":false,"given":"Yuxuan","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia  Yinchuan 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