{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:05:11Z","timestamp":1790139911807,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anthropogenic activities and the large volume of compounds released into the environment are sources of contamination for plants, animals, and humans. The herbicide monosodium methyl arsenate (MSMA) ranks among the best\u2010selling agricultural pesticides in Brazil. It is classified as highly toxic, containing arsenic, which crosses the placenta, reaching the developing embryo. To assess the toxic effects of these chemicals, model organisms such as chicken embryos are used, as they share phylotypic features with human embryos in the early stages of development, allowing extrapolation between species. This study aimed to identify developmental alterations in chicken embryos induced by MSMA exposure after 3 and 7\u2009days of incubation. The experiment involved three groups of fertilized eggs injected with 0.079, 0.79, and 7.9\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    of an MSMA solution, along with two control groups. We collected embryos to assess mortality rates, morphometric measurements, and morphological alterations. MSMA exposure was associated with embryo mortality, with a statistically significant increase in mortality observed in the MSMA II group after 7\u2009days of incubation, and a non\u2010significant tendency toward higher mortality in the remaining treated groups at the same period. Seven\u2010day embryos exposed to MSMA exhibited significant reductions in embryo area and head, limb, and trunk length. Furthermore, MSMA exposure led to malformations in the cephalic region, neural tube, heart, optic vesicle, limbs, and beak, along with abnormal body curvature and body wall. These anomalies correspond to congenital disorders reported in humans, such as anencephaly, myelomeningocele, and skeletal malformations. These outcomes reveal the harmful effects of MSMA on chicken embryo development and suggest potential risks for human embryogenesis.\n                  <\/jats:p>","DOI":"10.1002\/tox.70194","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:25:42Z","timestamp":1790137542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Embryotoxic Effects of Monosodium Methyl Arsenate (\n                    <scp>MSMA<\/scp>\n                    ) on\n                    <i>Gallus gallus<\/i>\n                    : Morphological and Morphometric Evidence of Developmental Disruptions"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2579-1189","authenticated-orcid":false,"given":"Daniel Moreira","family":"Melo","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo  S\u00e3o Mateus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9529-6055","authenticated-orcid":false,"given":"Eduarda Scalfoni","family":"Tavares","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo  S\u00e3o Mateus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-5091","authenticated-orcid":false,"given":"Melyssa","family":"Kmecick","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-6503","authenticated-orcid":false,"given":"Juliana Castro Monteiro","family":"Pirovani","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo  S\u00e3o Mateus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7476\/9788575413173","volume-title":"\u00c9 Veneno ou \u00e9 Rem\u00e9dio? Agrot\u00f3xicos, Sa\u00fade e Ambiente","author":"Peres F.","year":"2003"},{"key":"e_1_2_12_3_1","volume-title":"Fundamento em Toxicologia de Casarett e Doull","author":"Klaassen C. D.","year":"2012"},{"issue":"2","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/S1413-81232002000200010","article-title":"Avalia\u00e7\u00e3o Integrada Do Impacto Do Uso de Agrot\u00f3xicos Sobre a Sa\u00fade Humana Em Uma Comunidade Agr\u00edcola de Nova Friburgo, RJ","volume":"7","author":"Moreira J. C.","year":"2002","journal-title":"Ci\u00eancia & Sa\u00fade Coletiva, Rio de Janeiro"},{"key":"e_1_2_12_5_1","volume-title":"Ger\u00eancia Geral de Toxicologia. 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