{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:51:21Z","timestamp":1791517881490,"version":"4.3.4"},"reference-count":121,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the chronic effects of chlordecone (CLD) and propylparaben (PP), two pro\u2010estrogenic endocrine disruptors, on\n                    <jats:italic>Hydra vulgaris<\/jats:italic>\n                    Pallas, 1766 using a multiscale approach over a 14\u2010day exposure period. Environmentally relevant concentrations of CLD (0.5, 5, 20\u2009\u03bcg\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and PP (0.01, 0.05, 0.40\u2009\u03bcg\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) were tested individually and in mixtures. CLD and PP single exposures reduced the asexual reproductive rate (RHR) by 20% at intermediate CLD and high PP concentrations, whereas mixtures caused stronger declines up to 60.0% at high concentration. Severe morphological damage occurred only under high\u2010dose mixtures. We analyzed the expression of 17 genes covering detoxification, oxidative stress, endocrine function, regeneration, neurotransmission, proteolysis, and epigenetic regulation. Except for\n                    <jats:italic>G6pd<\/jats:italic>\n                    and\n                    <jats:italic>Thypedin<\/jats:italic>\n                    , single exposures to CLD and PP either increased or decreased gene expression. Only a limited subset of genes (\n                    <jats:italic>Cyp17\u2010like<\/jats:italic>\n                    and\n                    <jats:italic>Cyp1a\u2010like<\/jats:italic>\n                    under CLD;\n                    <jats:italic>Cyp17\u2010like<\/jats:italic>\n                    ,\n                    <jats:italic>G6pd<\/jats:italic>\n                    , and\n                    <jats:italic>Thypedin<\/jats:italic>\n                    under PP) displayed dose\u2010related tendencies, while most other genes showed non\u2010monotonic or irregular responses typical of endocrine disruptors. Mixture effects included antagonism, potentiation, and coalition, with non\u2010monotonic responses such as\n                    <jats:italic>Cyp17\u2010like<\/jats:italic>\n                    induction showing a 2\u2010fold increase at low concentration and reversal or neutralization of oxidative\u2010stress markers. Mixtures also increased ubiquitin in damaged hydras exposed to high\u2010dose mixtures and reduced global DNA methylation (up to \u221243%). Together, these results highlight that mixture effects diverge markedly from single\u2010compound responses, show no additive effects, reinforce the importance of assessing endocrine disruptors in combination, and confirm the relevance of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. vulgaris<\/jats:italic>\n                    <\/jats:styled-content>\n                    as a sensitive model at environmental concentrations.\n                  <\/jats:p>","DOI":"10.1002\/tox.70201","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:41:34Z","timestamp":1791517294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiscale Effects of Environmentally Relevant Mixtures Containing Two Estrogenic Endocrine Disruptors, Chlordecone and Propylparaben, in\n                    <i>Hydra vulgaris<\/i>\n                    Pallas, 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