{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:52:06Z","timestamp":1791474726809,"version":"4.3.4"},"reference-count":83,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872949"],"award-info":[{"award-number":["81872949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsess.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Genome"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    Bunge, also known as red sage or Danshen, is an important traditional Chinese medicine (TCM) that has been used for thousands of years to treat cardiovascular and other diseases. It is also considered an important model TCM plant. Here, a high\u2010quality reference genome of\n                    <jats:italic>S. miltiorrhiza<\/jats:italic>\n                    was generated by combining PacBio long\u2010read sequencing and chromatin interaction mapping (Hi\u2010C) technologies, resulting in the chromosome\u2010scale assembly of a 594.75\u2010Mb genome sequence with a contig N50 of 2.70 Mb. This assembly shows the highest level of continuity for a Danshen genome generated thus far. The\n                    <jats:italic>S. miltiorrhiza<\/jats:italic>\n                    genome contained 32,483 protein\u2010coding genes, with a repetitive DNA content of approximately 64.84%. The high percentage of young LTRs suggests that multiple TE transposition bursts occurred recently in\n                    <jats:italic>S. miltiorrhiza<\/jats:italic>\n                    . Genes unique to secondary metabolism pathways were expanded in the\n                    <jats:italic>S. miltiorrhiza<\/jats:italic>\n                    genome. A new CYP450 gene cluster was identified in the phloem of red roots where active components were synthesized. This reference genome sequence will facilitate future studies aimed at the elucidation of the secondary metabolism synthesis pathway and the genetic improvement of\n                    <jats:italic>S. miltiorrhiza<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/tpg2.20041","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T01:54:13Z","timestamp":1600394053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["A high\u2010quality reference genome sequence of\n                    <i>Salvia miltiorrhiza<\/i>\n                    provides insights into tanshinone synthesis in its red rhizomes"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhenqiao","family":"Song","sequence":"first","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"},{"name":"State Key Laboratory of Crop Biology Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caicai","family":"Lin","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyi","family":"Xing","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fen","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Q.","family":"Gu","sequence":"additional","affiliation":[{"name":"Crop Improvement &amp; Genetics Research, Western Regional Research Center USDA\u2010ARS  Albany CA 94710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Agronomy College Shandong Agricultural University  Tai'an Shandong 271028 China"},{"name":"State Key Laboratory of Crop Biology Shandong Agricultural University  Tai'an Shandong 271028 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