{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:40:41Z","timestamp":1791380441361,"version":"4.3.3"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsess.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Genome"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pea (\n                    <jats:italic>Pisum sativum<\/jats:italic>\n                    L.) is an essential legume crop cultivated globally as food and feed. However, its production is greatly constrained by\n                    <jats:italic>Fusarium oxysporum<\/jats:italic>\n                    f. sp.\n                    <jats:italic>pisi<\/jats:italic>\n                    (\n                    <jats:italic>Fop<\/jats:italic>\n                    ). Breeding for resistance is the most efficient management strategy, but the genetic foundation of\n                    <jats:italic>Fop<\/jats:italic>\n                    resistance remains unclear. Previous quantitative trait loci mapping has located several genomic regions associated with resistance to\n                    <jats:italic>Fop<\/jats:italic>\n                    . However, the large marker\u2010trait distances hampered the implementation of marker\u2010assisted selection. To unravel candidate genes for\n                    <jats:italic>Fop<\/jats:italic>\n                    races 1 and 2, diversity array technology (DArT) markers were applied to 324 pea core collections for a genome\u2010wide association study (GWAS). Phenotyping of the collections were performed under controlled growth chamber conditions with three independent experiments in a 324\u00a0\u00d7\u00a03\u00a0\u00d7\u00a07 factorial design. The collections were inoculated, and disease incidence was quantified over time using the area under the disease progress curve as the primary phenotypic measure for analyses. Phenotypic results revealed quantitative response and implicated wild accessions and landraces as favorable reservoirs of\n                    <jats:italic>Fop<\/jats:italic>\n                    resistance. GWAS using 26,045 DArT markers with three different models detected 15 marker\u2010trait associations (MTAs) for\n                    <jats:italic>Fop<\/jats:italic>\n                    race 1 and 27 MTAs for\n                    <jats:italic>Fop<\/jats:italic>\n                    race 2 resistance. MTAs were scattered across six pea chromosomes, with several of them located within the confidence interval of four previous\n                    <jats:italic>Fop<\/jats:italic>\n                    resistance loci\n                    <jats:italic>\u2014<\/jats:italic>\n                    thereby refining their location. In addition, 28 potential candidate genes were identified near associated markers involved in\n                    <jats:italic>Fop<\/jats:italic>\n                    resistance, including genes encoding a reverse transcriptase, exocyst and conserved oligomeric Golgi complex subunits, a FERONIA\u2010like receptor kinase, homoserine kinase, a heat shock 70 protein, adenosine triphosphate transporters, and multiple transcription factors and plant defense\u2010related proteins. These putative genes and molecular pathways provide a foundation for the sustainable management of\n                    <jats:italic>Fop<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/tpg2.70250","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:03:00Z","timestamp":1779433380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome\u2010wide association studies of a pea germplasm reveal novel markers and candidate genes implicated in resistance to\n                    <i>Fusarium oxysporum<\/i>\n                    f. sp.\n                    <i>pisi<\/i>\n                    races 1 and 2"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-1074","authenticated-orcid":false,"given":"Osman Zakaria","family":"Wohor","sequence":"first","affiliation":[{"name":"Institute for Sustainable Agriculture CSIC  Cordoba Spain"},{"name":"Savanna Agriculture Research Institute, CSIR  Tamale, Nyankpala Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-8616","authenticated-orcid":false,"given":"Diego","family":"Rubiales","sequence":"additional","affiliation":[{"name":"Institute for Sustainable Agriculture CSIC  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0273","authenticated-orcid":false,"given":"Nicolas","family":"Rispail","sequence":"additional","affiliation":[{"name":"Institute for Sustainable Agriculture CSIC  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.00199"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103059.2011.02537.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22877"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erab549"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcu074"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010arplant\u2010102820\u2010103424"},{"key":"e_1_2_11_10_1","first-page":"20","article-title":"Chromosomal location of Fwf, the Fusarium wilt race 5 resistance gene in Pisum sativum","volume":"32","author":"Coyne C. J.","year":"2000","journal-title":"Pisum Genetics"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1320506"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2023.102482"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122\u2010024\u201004682\u20101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy12061354"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-418672-9.00004-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u20100162429\u20104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341x.1999.00997.x"},{"key":"e_1_2_11_18_1","volume-title":"Crops and livestock products","author":"FAOSTAT","year":"2025"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870\u2010018\u20101368\u20104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.01538"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.00323"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203\u2010025\u201004545\u20103"},{"key":"e_1_2_11_23_1","first-page":"1","article-title":"The water\u2010culture method for growing plants without soil","volume":"347","author":"Hoagland D. R.","year":"1938","journal-title":"California Agricultural Experiment Station Circular"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.113.113605"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy154"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koad319"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10681\u2010006\u20106963\u2010z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2135\/cropsci2015.02.0102"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn129"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102156\u201011\u201094"},{"key":"e_1_2_11_31_1","unstructured":"Kassambara A.(2023).rstatix: Pipe\u2010Friendly Framework for Basic Statistical Tests(R package version 0.7. 2).https:\/\/cran.r\u2010project.org\/web\/packages\/rstatix\/index.html"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/17429145.2022.2041743"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100480\u20101"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12577"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00490"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1189289"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870\u2010025\u201008052\u2010x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001867\u20108"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005767"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11111389"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.43"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.21273\/JASHS.127.4.602"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100523.2011.01938.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.21273\/JASHS.124.1.28"},{"issue":"1","key":"e_1_2_11_45_1","first-page":"208","article-title":"Quantitative trait locus (QTL) analysis","volume":"1","author":"Myles C.","year":"2008","journal-title":"Nature Education"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.4141\/P02\u2010048"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299\u2010016\u20101993\u2010z"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091226"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041\u2010210x.13384"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477\u2010021\u201001028\u20103"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147920"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20510"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122\u2010020\u201003751\u20105"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.074229"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3198\/jpr2013.07.0041crg"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.136093"},{"key":"e_1_2_11_57_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2024"},{"key":"e_1_2_11_58_1","first-page":"93","volume-title":"Histidine phosphorylation: Methods and protocols","author":"Rigden D. J.","year":"2019"},{"key":"e_1_2_11_59_1","volume-title":"Dataset for genetic diversity and population structure of a wide Pisum spp. core collection","author":"Rispail N.","year":"2022"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032470"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011926"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.70164"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/00307270231195641"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture13091825"},{"key":"e_1_2_11_65_1","first-page":"575","volume-title":"Achieving sustainable cultivation of vegetables","author":"Rubiales D.","year":"2019"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20154"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122\u2010014\u20102375\u2010y"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.1035878"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy2020074"},{"key":"e_1_2_11_70_1","unstructured":"Storey J. D. Bass A. J. Dabney A. &Robinson D.(2024).qvalue: Q\u2010Value Estimation for False Discovery Rate Control. (R package version 2.36. 0.).http:\/\/github.com\/jdstorey\/qvalue"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1123631"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2015.01037"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.109.066811"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103\u2010025\u201001624\u20103"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2237-7_13"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2021.08.005"},{"key":"e_1_2_11_77_1","unstructured":"Wang Q.(2016).QQperm: Permutation Based QQ Plot and Inflation Factor Estimation(R package version 1.0.1.) \u00a0https:\/\/cran.r\u2010project.org\/web\/packages\/QQperm"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/leg3.250"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11192664"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122\u2010025\u201005051\u20102"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18568"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001172\u20102"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103\u2010005\u20102910\u2010y"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2020.10.007"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1702"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13593\u2010016\u20100365\u2010y"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.06.075"}],"container-title":["The Plant Genome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tpg2.70250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tpg2.70250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tpg2.70250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:30:05Z","timestamp":1782387005000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/10.1002\/tpg2.70250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/tpg2.70250"],"URL":"https:\/\/doi.org\/10.1002\/tpg2.70250","archive":["Portico"],"relation":{},"ISSN":["1940-3372","1940-3372"],"issn-type":[{"value":"1940-3372","type":"print"},{"value":"1940-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70250"}}