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For this purpose, we developed a bioinformatic pipeline to retrieve and integrate stress\u2010related RNA\u2010seq transcriptomic data from species of interest and identify core species\u2010specific and cross\u2010species conserved genes and processes involved in stress responses. We utilized this approach to investigate the molecular mechanisms underpinning drought response in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    ,\n                    <jats:italic>Triticum aestivum<\/jats:italic>\n                    , and\n                    <jats:italic>Solanum lycopersicum<\/jats:italic>\n                    . We found that hormone signaling, reactive oxygen species catabolism, cell wall organization, photosynthesis, and defense mechanisms were dysregulated in response to drought in at least two species.\u00a0Among the identified cross\u2010species conserved differentially expressed genes,\n                    <jats:italic>PUB19<\/jats:italic>\n                    ,\n                    <jats:italic>EDL3<\/jats:italic>\n                    ,\n                    <jats:italic>RAB18<\/jats:italic>\n                    , and\n                    <jats:italic>AAP6<\/jats:italic>\n                    confirmed to play a key role in drought response. Coexpression networks identified central genes underpinning drought\u2010response, such as\n                    <jats:italic>HB\u20107<\/jats:italic>\n                    in leaves and\n                    <jats:italic>P5CS1<\/jats:italic>\n                    in roots. Leveraging PlantConnectome, several drought\u2010responsive genes not classified as such in Gene Ontology were also detected, including\n                    <jats:italic>EULS3<\/jats:italic>\n                    ,\n                    <jats:italic>PUB19<\/jats:italic>\n                    ,\n                    <jats:italic>BFT<\/jats:italic>\n                    ,\n                    <jats:italic>DAA1<\/jats:italic>\n                    , involved in carbohydrate recognition, ubiquitination, abscisic acid signaling, and membrane integrity maintenance, highlighting the need for further investigation. In conclusion, the developed approach proved effective in identifying core drought\u2010responsive genes and processes and has the potential to be applied to other plant species and types of stress.\n                  <\/jats:p>","DOI":"10.1002\/tpg2.70311","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:00:14Z","timestamp":1791518414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010species transcriptomics uncovers shared responses to water deficiency in plants"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5694-6079","authenticated-orcid":false,"given":"Francesco","family":"Punzi","sequence":"first","affiliation":[{"name":"Institute of Biosciences and Bioresources, National Research Council (CNR\u2010IBBR)  Bari Italy"},{"name":"Department of Soil, Plant and Food Sciences University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-1570","authenticated-orcid":false,"given":"Diana Lucia","family":"Zuluaga","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Bioresources, National Research Council (CNR\u2010IBBR)  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-7478","authenticated-orcid":false,"given":"Qiao Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-0126","authenticated-orcid":false,"given":"Marek","family":"Mutwil","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-6828","authenticated-orcid":false,"given":"Gabriella","family":"Sonnante","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Bioresources, National Research Council (CNR\u2010IBBR)  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-3029","authenticated-orcid":false,"given":"Pasquale Luca","family":"Curci","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Bioresources, National Research Council (CNR\u2010IBBR)  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142\u2010021\u201000821\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201054623\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.896945"},{"key":"e_1_2_10_5_1","unstructured":"Blighe K. 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