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Eligible patients need to have amyloid \u03b2 (A\u03b2) loads examined by Pittsburgh compound B (PiB) positron emission tomography (PET) or decreased A\u03b2 level in cerebrospinal fluid. Participants will be randomized into either a 40\u00a0Hz tACS group or a sham stimulation group. Both groups will undergo 30 one\u2010hour sessions across 3\u00a0weeks (21 days). The outcome measures will be assessed at baseline, at the end of the intervention, and 3 months after the first session. The primary outcome is global cognitive function, assessed by the 11\u2010item cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS\u2010Cog), and the secondary outcomes include changes in other neuropsychological assessments and in PiB\u2010PET, structural magnetic resonance imaging (MRI), resting electroencephalography (EEG), and simultaneous EEG\u2013functional MRI (EEG\u2010fMRI) results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The trial is currently ongoing, and it is anticipated that recruitment will be completed in June 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This trial will evaluate the efficacy and safety of 40\u00a0Hz tACS in patients with AD, and further explore the potential mechanisms by analyzing amyloid deposits using PiB\u2010PET, brain volume and white matter integrity by structural MRI, and neural activity by EEG and EEG\u2010fMRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12005","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T04:11:08Z","timestamp":1586319068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TRanscranial AlterNating current Stimulation FOR patients with Mild Alzheimer's Disease (TRANSFORM\u2010AD study): Protocol for a randomized controlled clinical trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Yi","family":"Xing","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders Department of Neurology, Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education of the People's 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