{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:19:18Z","timestamp":1789683558986,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":132,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol\u2010Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable\u2010adjusted Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in \u201cever\u201d smokers than in \u201cnever\u201d smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in \u201cever\u201d smokers and those who were \u201cnormal\u201d to \u201coverweight\u201d versus \u201cnever\u201d smokers or those who were \u201cobese,\u201d respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A moderate intake of flavonoid\u2010rich foods may help to reduce dementia risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12175","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T12:21:15Z","timestamp":1620908475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort"],"prefix":"10.1002","volume":"7","author":[{"given":"Catherine P.","family":"Bondonno","sequence":"first","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"},{"name":"School of Biomedical Sciences Royal Perth Hospital University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P.","family":"Bondonno","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"},{"name":"School of Biomedical Sciences Royal Perth Hospital University of Western Australia  Perth Australia"},{"name":"Institute for Global Food Security Queen's University Belfast  Belfast Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Dalgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev &amp; Gentofte University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Gardener","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research &amp; Care School of Medical and Health Sciences Edith Cowan University  Joondalup Australia"},{"name":"Australian Alzheimer's Research Foundation  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research &amp; Care School of Medical and Health Sciences Edith Cowan University  Joondalup Australia"},{"name":"Australian Alzheimer's Research Foundation  Perth Australia"},{"name":"Department of Biomedical Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research &amp; Care School of Medical and Health Sciences Edith Cowan University  Joondalup Australia"},{"name":"Australian Alzheimer's Research Foundation  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aed\u00edn","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security Queen's University Belfast  Belfast Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"},{"name":"School of Biomedical Sciences Royal Perth Hospital University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Croft","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Royal Perth Hospital University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Kyr\u00f8","sequence":"additional","affiliation":[{"name":"The Danish Cancer Society Research Centre  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev &amp; Gentofte University Hospital  Copenhagen Denmark"},{"name":"The National Institute of Public Health University of Southern Denmark  Odense Denmark"},{"name":"The Danish Heart Foundation  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Scalbert","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"The Danish Cancer Society Research Centre  Copenhagen Denmark"},{"name":"Department of Public Health Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Hodgson","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"},{"name":"School of Biomedical Sciences Royal Perth Hospital University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Alzheimer report 2018: the state of the art of dementia research: new frontiers","author":"Patterson C","year":"2018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1311405"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00062-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11622-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430040053006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuu014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003934"},{"key":"e_1_2_8_12_1","first-page":"93","article-title":"Dietary flavonoid intake and cognitive performance in older adults with Alzheimer's type dementia","volume":"5","author":"Caldwell K","year":"2016","journal-title":"J Aging Res Clin Pract"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23594"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm036"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007614613771"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.144"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh124"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005607"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1330-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(19)30212-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bap024"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.007096"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30065-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000269933"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107084"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft355"},{"key":"e_1_2_8_30_1","volume-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2019"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007617"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0094-x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa079"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30338-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.637835"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.073106"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.311908"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.1.38"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12351"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.09.030"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049493"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz178"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-009-0037-3"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00536"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3850"},{"key":"e_1_2_8_48_1","first-page":"1","article-title":"Acute effects of flavonoid\u2010rich blueberry on cognitive and vascular function in healthy older adults","author":"Dodd GF","year":"2019","journal-title":"Nutr Health Aging"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1083-y"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.092189"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-1615"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.06.005"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32831b9c6e"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008981"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118333"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.05.018"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt176"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58109"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.136051"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.12175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.12175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.12175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:12:34Z","timestamp":1761480754000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.12175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/trc2.12175"],"URL":"https:\/\/doi.org\/10.1002\/trc2.12175","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12175"}}