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Western\u2010style dietary patterns are considered to increase the risk, whereas Mediterranean\u2010style dietary patterns are considered to reduce the risk. An association between diet and AD\u2010related biomarkers have been suggested, but studies are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate potential relations between dietary patterns and cerebrospinal fluid (CSF) biomarkers for AD among dementia\u2010free older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were derived from the population\u2010based Gothenburg H70 Birth Cohort Studies, Sweden. A total of 269 dementia\u2010free 70\u2010year\u2010olds with dietary and cerebrospinal fluid (CSF) amyloid beta (A\u03b242 and A\u03b240), total tau (t\u2010tau), and phosphorylated tau (p\u2010tau) data were investigated. Dietary intake was determined by the diet history method, and four dietary patterns were derived by principal component analysis. A Western dietary pattern, a Mediterranean\/prudent dietary pattern, a high\u2010protein and alcohol pattern, and a high\u2010total and saturated fat pattern. Logistic regression models, with CSF biomarker pathology (yes\/no) as dependent variables, and linear regression models with continuous CSF biomarker levels as dependent variables were performed. The analyses were adjusted for sex, energy intake, body mass index (BMI), educational level, and physical activity level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The odds ratio for having total tau pathology (odds ratio [OR] 1.43; 95% confidence interval [CI] 1.02 to 2.01) and preclinical AD (A\u03b242 and tau pathology; OR 1.79; 95% CI 1.03 to 3.10) was higher among those with a higher adherence to a Western dietary pattern. There were no other associations between the dietary patterns and CSF biomarkers that remained significant in both unadjusted and adjusted models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest that higher adherence to a Western dietary pattern may be associated with pathological levels of AD biomarkers in the preclinical phase of AD. These findings can be added to the increasing amount of evidence linking diet with AD and may be useful for future intervention studies investigating dietary intake in relation to AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12183","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T04:26:27Z","timestamp":1621311987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Western\u2010style dietary pattern is associated with cerebrospinal fluid biomarker levels for preclinical Alzheimer's disease\u2014A population\u2010based cross\u2010sectional study among 70\u2010year\u2010olds"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-6720","authenticated-orcid":false,"given":"Jessica","family":"Samuelsson","sequence":"first","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry 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