{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:18:21Z","timestamp":1761481101931,"version":"build-2065373602"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["678304"],"award-info":[{"award-number":["678304"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010IAIHU\u201006","ANR\u201019\u2010P3IA\u20100001"],"award-info":[{"award-number":["ANR\u201010\u2010IAIHU\u201006","ANR\u201019\u2010P3IA\u20100001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aim to understand how patients with Alzheimer's disease (AD) are treated by identifying in a longitudinal fashion the late\u2010life changes in patients\u2019 medical history that precede and follow AD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We use prescription history of 34,782 patients followed between 1996 and 2019 by French general practitioners. We compare patients with an AD diagnosis, patients with mild cognitive impairment (MCI), and patients free of mental disorders. We use a generalized mixed\u2010effects model to study the longitudinal changes in the prescription of eight drug types for a period 15 years before diagnosis and 10 years after.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the decades preceding diagnosis, we find that future AD patients are treated significantly more than MCI patients with most psychotropic drugs and that most studied drugs are increasingly prescribed with age. At the time of diagnosis, all psychotropic drugs except benzodiazepines show a significant increase in prescription, while other drugs are significantly less prescribed. In the 10 years after diagnosis, nearly all categories of drugs are less and less prescribed including antidementia drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Pre\u2010diagnosis differences between future AD patients and MCI patients may indicate that subtle cognitive changes are recognized and treated as psychiatric symptoms. The disclosure of AD diagnosis drastically changes patients\u2019 care, priority being given to the management of psychiatric symptoms. The decrease of all prescriptions in the late stages may reflect treatment discontinuation and simplification of therapeutic procedures. This study therefore provides new insights into the medical practices for management of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12210","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:01:11Z","timestamp":1631610071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in the use of psychotropic drugs during the course of Alzheimer's disease: A large\u2010scale longitudinal study of French medical records"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-2908","authenticated-orcid":false,"given":"Manon","family":"Ansart","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 06 Inserm CNRS Institut du cerveau et la moelle \u00e9pini\u00e8re (ICM) \u2010 H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Inria Paris Aramis project\u2010team  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