{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:37Z","timestamp":1792259257622,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G\u2010protein coupled receptor, is implicated in neurological disorders but its role in VCI is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed GPR39 immunohistochemical analysis in\n                      <jats:italic>post mortem<\/jats:italic>\n                      brain samples from mild cognitive impairment (MCI) and control subjects. DNA was analyzed for GPR39 single nucleotide polymorphisms (SNPs), and correlated with white matter hyperintensity (WMH) burden on\n                      <jats:italic>pre mortem<\/jats:italic>\n                      magnetic resonance imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GPR39 is expressed in aged human dorsolateral prefrontal cortex, localized to microglia and peri\u2010capillary cells resembling pericytes. GPR39\u2013capillary colocalization, and density of GPR39\u2010expressing microglia was increased in aged brains compared to young. SNP distribution was equivalent between groups; however, homozygous SNP carriers were present only in the MCI group, and had higher WMH volume than wild\u2010type or heterozygous SNP carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>GPR39 may play a role in aging\u2010related VCI, and may serve as a therapeutic target and biomarker for the risk of developing VCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12214","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T03:23:15Z","timestamp":1634613795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment"],"prefix":"10.1002","volume":"7","author":[{"given":"Catherine M.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Perioperative Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierno M.","family":"Bah","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Perioperative Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenri H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Perioperative Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine Oregon Health &amp; Science University  Portland Oregon 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