{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:14:33Z","timestamp":1782220473099,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":320,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009874","name":"Universit\u00e9 de Sherbrooke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose\u2010specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or ketone uptake in specific WM fascicles in MCI has not previously been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This 6\u2010month interventional study included MCI participants randomized to a placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016) or ketogenic medium chain triglyceride (kMCT;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017) drink. A neurocognitive battery and brain imaging were performed pre\u2010 and post\u2010intervention. WM fascicle uptake of ketone and glucose and structural properties were assessed using positron emission tomography and diffusion imaging, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ketone uptake was increased in the kMCT group by 2.5\u2010 to 3.2\u2010fold in all nine WM fascicles of interest (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), an effect seen both in deep WM and in fascicle cortical endpoints. Improvement in processing speed was positively associated with WM ketone uptake globally and in individual fascicles, most importantly the fornix (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0+0.61;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>A 6\u2010month kMCT supplement improved WM energy supply in MCI by increasing ketone uptake in WM fascicles. The significant positive association with processing speed suggests that ketones may have a role in myelin integrity in MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12217","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T04:41:33Z","timestamp":1637124093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment"],"prefix":"10.1002","volume":"7","author":[{"given":"Maggie","family":"Roy","sequence":"first","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"},{"name":"Department of Pharmacology and Physiology Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Department of Computer Science Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Fortier","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rheault","sequence":"additional","affiliation":[{"name":"Department of Computer Science Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Edde","sequence":"additional","affiliation":[{"name":"Department of Computer Science Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Croteau","sequence":"additional","affiliation":[{"name":"Centre de Recherche\u2010CHUS CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"},{"name":"Sherbrooke Molecular Imaging Center Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian\u2010Alexandre","family":"Castellano","sequence":"additional","affiliation":[{"name":"Centre de Recherche\u2010CHUS CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Langlois","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"St\u2010Pierre","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cuenoud","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Health Science  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bocti","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"},{"name":"Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Fulop","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"},{"name":"Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Descoteaux","sequence":"additional","affiliation":[{"name":"Department of Computer Science Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"Research Center on Aging CIUSSS de l'Estrie\u2013CHUS  Sherbrooke Quebec Canada"},{"name":"Department of Pharmacology and Physiology Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051183"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx355"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.13.45"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705036104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.09.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479508"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2014.05.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200213"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u20100072\u2010x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa073"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12206"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.12.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/17.5.293"},{"key":"e_1_2_7_18_1","volume-title":"Delis\u2010Kaplan Executive Function System (D\u2010KEFS)","author":"Delis D","year":"2001"},{"key":"e_1_2_7_19_1","volume-title":"Wechsler Memory Scale","author":"Wechsler D","year":"1997"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.027"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.09.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116889"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_7_24_1","first-page":"2267","article-title":"Diffusion tensor tractography of the limbic system","volume":"26","author":"Concha L","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.04.518"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.2004424"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.016"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.029"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1179-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.015"},{"key":"e_1_2_7_31_1","volume-title":"Analyse et reconstruction de faisceaux de la mati\u00e8re blanche","author":"Rheault F","year":"2020"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161163"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.020"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049790"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37658-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.040"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1097-5"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.11.002"},{"key":"e_1_2_7_40_1","volume-title":"Increased Conduction Velocity as a Result of Myelination","author":"Purves D","year":"2001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704107030"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.128"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506124"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00059"},{"key":"e_1_2_7_45_1","first-page":"142","article-title":"Correlations between Limbic White Matter and Cognitive Function in Temporal\u2010Lobe Epilepsy","volume":"6","author":"Alexander RP","year":"2014","journal-title":"Preliminary Findings Front Aging Neurosci"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22119"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190875"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv338"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.09.018"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2016.11.013"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.12217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.12217","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.12217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:13:20Z","timestamp":1761480800000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.12217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/trc2.12217"],"URL":"https:\/\/doi.org\/10.1002\/trc2.12217","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.03.18.21253884","asserted-by":"object"}]},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12217"}}