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Even though molecular events signal possible onset of cognitive disorders decades prior to their clinical diagnoses, cognition and its possible early changes in midlife remain poorly understood. We characterize midlife cognition in a cognitively healthy population\u2010based sample using the Cogstate Brief Battery and test for associations with cardiovascular, adiposity\u2010related, lifestyle\u2010associated, and psychosocial variables. Learning and working memory showed significant variability and vulnerability to psychosocial influences in midlife. Furthermore, midlife aging significantly and progressively increased prevalence of suboptimal cognitive performance. Our findings suggest that physiological changes in cognition, measured with simple tests suitable for use in everyday clinical setting, may signal already in midlife the first clinical manifestations of the presymptomatic biologically defined cognitive disorders. This pilot study calls for longitudinal studies investigating midlife cognition to identify clinical correlates of biologically defined cognitive disorders.<\/jats:p>","DOI":"10.1002\/trc2.12234","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T06:42:17Z","timestamp":1640932937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating cognition in midlife"],"prefix":"10.1002","volume":"7","author":[{"given":"Jan S.","family":"Novotn\u00fd","sequence":"first","affiliation":[{"name":"Translational Aging and Neuroscience Program, Centre for Translational Medicine, International Clinical Research Centre St.\u00a0Anne's University Hospital  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Gonzalez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Kardiovize Study, International Clinical Research Centre St. Anne's University Hospital  Brno Czech Republic"},{"name":"Department of Global Health and Population Harvard TH Chan School of Public Health Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Medina\u2010Inojosa","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lopez\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonas E.","family":"Geda","sequence":"additional","affiliation":[{"name":"Division of Alzheimer's Disease and Memory Disorders Program Department of Neurology Barrow Neurological Institute  Phoenix Arizona 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