{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:14:10Z","timestamp":1778580850715,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&D Transl Res & Clin Interv"],"published-print":{"date-parts":[[2022,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Individuals in the Alzheimer's disease (AD) continuum with mild cognitive impairment (prodromal AD) are at increased risk to develop dementia. Still, underlying pathophysiological processes remain unclear. We studied whether cerebrospinal fluid (CSF) proteome changes are related to time to clinical progression in prodromal AD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We measured 671 CSF proteins in 49 prodromal AD individuals (67\u00b17 years old, 22 [45%] female) from the Amsterdam Dementia Cohort. Associations of protein levels with time to dementia onset were tested with Cox regression models, followed by biological pathway enrichment analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighteen (36%) individuals developed dementia during follow\u2010up. In total, 128 (98%) proteins were associated with a 1.4\u2010 to 17\u2010fold increased risk of progression to dementia (all\n P<\/jats:italic>\n \u00a0<\u00a0.05). These proteins showed enrichment for immune system processes, signal transduction, neuronal death, and neurodevelopmental biology.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n CSF proteome changes related to rate of progression to dementia can be detected in prodromal AD, providing more insight into processes involved in early AD pathophysiology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/trc2.12240","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T03:54:29Z","timestamp":1645588469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CSF proteomic signature predicts progression to Alzheimer's disease dementia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-5500","authenticated-orcid":false,"given":"Eleonora M.","family":"Vromen","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"del Campo Mil\u00e1n","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud Facultad de Farmacia CEU Universities Urbanizaci\u00f3n Montepr\u00edncipe Universidad San Pablo\u2010CEU Alcorc\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Department of Psychiatry Maastricht University Maastricht the Netherlands"},{"name":"Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.130518"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12014-020-09276-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2019.1670613"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0795-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0335-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.366"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132306"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.281055"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_7_15_1","unstructured":"Olink.com.2021.Home \u2010 Olink. 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