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Will medium chain triglyceride (MCT) oil, a nutritional source of ketones, impact cognition in AD?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a 6\u2010month randomized, double\u2010blind, placebo\u2010controlled, crossover study, with 6\u2010month open\u2010label extension in probable AD subjects, on stable medications. MCT dose was 42\u00a0g\/day, or maximum tolerated. Cognition was assessed with Mini\u2010Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Cognigram\u00ae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty subjects, average age 72.6 years, 45% women, 70% university educated had baseline MMSE 22.6\/30 (10\u201329); MoCA 15.6\/30 (4\u201327); baseline Cognigram\u00ae Part 1: 65\u2013106, Part 2: 48\u2013107. Average MCT oil consumption was 1.8 tablespoons\/day (25.2\u00a0g, 234\u00a0kcal). Eighty percent remained stable or improved. Longer MCT exposure and age\u00a0&gt;\u00a073, resulted in higher final MMSE (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and Cognigram\u00ae 1 scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This is the longest duration MCT AD study to date. Eighty percent had stabilization or improvement in cognition, and better response with 9\u2010month continual MCT oil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12259","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T05:39:32Z","timestamp":1647236372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double\u2010blind, placebo\u2010controlled, crossover study, with an open\u2010label extension"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-1362","authenticated-orcid":false,"given":"Angela G.","family":"Juby","sequence":"first","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta 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