{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:57:05Z","timestamp":1788375425401,"version":"build-2803163510"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Age\u2010related neuropathology associated with sporadic Alzheimer's disease (AD) often develops well before the onset of symptoms. Given AD's long preclinical period, translational models are needed to identify early signatures of pathological decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using structural magnetic resonance imaging and cognitive assessments, we examined the relationships among age, cognitive performance, and neuroanatomy in 48 vervet monkeys (\n                      <jats:italic>Chlorocebus aethiops sabaeus<\/jats:italic>\n                      ) ranging from young adults to very old.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found negative associations of age with cortical gray matter volume (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003) and the temporal\u2010parietal cortical thickness meta\u2010region of interest (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001). Additionally, cortical gray matter volumes predicted working memory at approximately 1\u2010year follow\u2010up (correct trials at the 20s delay [\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.008]; correct responses after longer delays [\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cortical gray matter diminishes with age in vervets in regions relevant to AD, which may increase risk of cognitive impairment. This study lays the groundwork for future investigations to test therapeutics to delay or slow pathological decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12284","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:39:30Z","timestamp":1647164370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early Alzheimer's disease\u2010like reductions in gray matter and cognitive function with aging in nonhuman primates"],"prefix":"10.1002","volume":"8","author":[{"given":"Brett M.","family":"Frye","sequence":"first","affiliation":[{"name":"Department of Pathology\/Comparative Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Gerontology Wake Forest School of 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