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To facilitate model development, we measured cerebrospinal fluid (CSF) concentrations of key biomarkers in healthy male and female cynomolgus and rhesus macaques. Amyloid beta (A\u03b240, A\u03b242), tau (total tau [t\u2010tau], phosphorylated tau [pThr181]), and neurofilament light (NfL) concentrations were measured in CSF of 82 laboratory\u2010housed, experimentally na\u00efve cynomolgus (n = 33) and rhesus (n = 49) macaques. A\u03b240 and A\u03b242 were significantly higher in rhesus, and female rhesus were higher than males. NfL and t\u2010tau were higher in males, and NfL was higher in rhesus macaques. p\u2010tau was not affected by species or sex. We also examined whether sample location (lumbar or cisterna puncture) affected concentrations. Sample acquisition site only affected NfL, which was higher in CSF from lumbar puncture compared to cisterna magna puncture. Establishing normative biomarker values for laboratory\u2010housed macaque monkeys provides an important resource by which to compare to monkey models of neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12289","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:50:48Z","timestamp":1649209848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-2706","authenticated-orcid":false,"given":"Emma L.","family":"Robertson","sequence":"first","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University  Kingston Ontario 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