{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:53:36Z","timestamp":1789638816723,"version":"4.0.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12293","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:41:16Z","timestamp":1649839276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Reduced dementia incidence after varicella zoster vaccination in Wales 2013\u20132020"],"prefix":"10.1002","volume":"8","author":[{"given":"Christian","family":"Schnier","sequence":"first","affiliation":[{"name":"Division of Infection Medicine University of Edinburgh Medical School  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Janbek","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lathe","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine University of Edinburgh Medical School  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine University of Edinburgh Medical School  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1495","article-title":"Past exposure to vaccines and subsequent risk of Alzheimer's disease","volume":"165","author":"Verreault R","year":"2001","journal-title":"CMAJ"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050491"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab115"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002868"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70236-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180266"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14795"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010020\u201001157\u20104"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12119"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/15333175211006504"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010171162"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003637"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.3.274"},{"key":"e_1_2_8_17_1","unstructured":"Welsh Government.Welsh Health Circular.2015."},{"key":"e_1_2_8_18_1","unstructured":"Public Health Wales. 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