{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:29:13Z","timestamp":1761496153576,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to test the efficacy of a nutritional blend (NB) in improving nutritional biomarkers and preventing cognitive decline among older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 1\u2010year randomized, double\u2010blind, multicenter, placebo\u2010controlled trial with 362 adults (58.6% female, mean 78.3 years, SD = 4.8) receiving an NB or placebo. Erythrocyte \u03c9\u20103 index and homocysteine concentrations were primary outcomes. Other outcomes included Patient\u2010Reported Outcomes Measurement Information System (PROMIS) Applied Cognition\u2010Abilities, composite cognitive score (CCS), Cognitive Function Instrument (CFI) self\u2010assessment and study partner, hippocampal volume (HV), and Alzheimer's disease signature cortical thickness (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 305 subjects completed the follow\u2010up. Supplementation increased \u03c9\u20103 index and decreased homocysteine, but did not affect CCS, CFI self\u2010assessment, HV, and CT. Placebo improved and treatment did not change PROMIS at 1 month. Intervention showed a positive effect on CFI study partner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Although improving nutritional biomarkers, this 1\u2010year trial with a multi\u2010nutrient novel approach was not able to show effects on cognitive outcomes among older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12314","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T14:35:03Z","timestamp":1664375703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A 1\u2010year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community\u2010dwelling older adults: The Nolan Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Kelly V.","family":"Giudici","sequence":"first","affiliation":[{"name":"Gerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III Inserm UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Cantet","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III Inserm UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III Inserm UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center  San Francisco California USA"},{"name":"Department of Medicine University of California  San Francisco California USA"},{"name":"Department of Psychiatry University of California  San Francisco California USA"},{"name":"Department of Neurology University of California  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Boschat","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 SA Nestl\u00e9 Research  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Hudry","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 SA Nestl\u00e9 Research  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Andrieu","sequence":"additional","affiliation":[{"name":"CERPOP UMR1295 University of Toulouse III Inserm UPS  Toulouse France"},{"name":"Department of Epidemiology and Public Health Toulouse University Hospital (CHU Toulouse)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse)  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III Inserm UPS  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen A. 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