{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:01Z","timestamp":1786978681661,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":297,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Free\u2010water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau\/inflammatory and amyloid positron emission tomography (PET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one participants underwent multi\u2010shell diffusion MRI,\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010THK5351 PET,\n                      <jats:sup>11<\/jats:sup>\n                      C\u2010Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (\n                      <jats:italic>n<\/jats:italic>\n                      = 40) and AD\u2010spectrum group (AD\u2010S) (\n                      <jats:italic>n<\/jats:italic>\n                      = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In AD\u2010S group, there was a significant positive correlation between FW and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010THK5351 and cognitive function in the same regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>FW imaging could be a biomarker for tau in AD alongside clinical correlations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12356","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:00:05Z","timestamp":1666681205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Free water derived by multi\u2010shell diffusion MRI reflects tau\/neuroinflammatory pathology in Alzheimer's 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