{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:21:25Z","timestamp":1780953685576,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World\u2010Wide FINGERS (WW\u2010FINGERS). As part of WW\u2010FINGERS, the Australian AU\u2010ARROW study mirrors aspects of FINGER, as well as US\u2010POINTER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHOD<\/jats:title>\n                    <jats:p>\n                      AU\u2010ARROW is a randomized, single\u2010blind, multisite, 2\u2010year clinical trial (\n                      <jats:italic>n<\/jats:italic>\n                      = 600; aged 55\u201379). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a global composite cognitive score. Extra value will emanate from blood biomarker analysis, positron emission tomography (PET) imaging, brain magnetic resonance imaging (MRI), and retinal biomarker tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The finalized AU\u2010ARROW protocol is expected to allow development of an evidence\u2010based innovative treatment plan to reduce cognitive decline and dementia risk, and effective transfer of research outcomes into Australian health policy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Study protocol for a single\u2010blind, randomized controlled trial, the AU\u2010ARROW Study.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The AU\u2010ARROW Study is a member of the World\u2010Wide FINGERS (WW\u2010FINGERS) initiative.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>AU\u2010ARROW's primary outcome measure is change in a global composite cognitive score.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Extra significance from amyloid PET imaging, brain MRI, and retinal biomarker tests.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Leading to development of an innovative treatment plan to reduce cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.12466","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T05:06:04Z","timestamp":1712639164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU\u2010ARROW): A study protocol for a single\u2010blind, multi\u2010site, randomized controlled trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-5260","authenticated-orcid":false,"given":"Samantha L.","family":"Gardener","sequence":"first","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research and Care School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Alzheimer's Research Australia Ralph and Patricia Sarich Neuroscience Research Institute  Nedlands 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