{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:27:36Z","timestamp":1785554856535,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG021155"],"award-info":[{"award-number":["R01 AG021155"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Recruitment and retention pose a significant challenge to Alzheimer's disease (AD) research. Returning AD biomarker results to participants has been proposed as a means to improve recruitment and retention. We present findings related to participant satisfaction, utility, and impact on research attitudes from the amyloid positron emission tomography (PET) disclosure sub\u2010study within the Wisconsin Registry for Alzheimer's Prevention (WRAP).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Ninety\u2010nine cognitively unimpaired WRAP participants learned their amyloid PET results (mean age \u00b1 SD\u00a0=\u00a072.0\u00a0\u00b1\u00a04.8). Measures of reasons for wanting to learn results, study comprehension, result utility, visit satisfaction, research attitudes, and future study enrollment willingness were collected. Between\u2010group, chi\u2010squared analysis was conducted to determine differences by result type (elevated vs. not elevated amyloid PET result) in study comprehension, result utility, and visit satisfaction. Linear mixed\u2010effects modeling was used to evaluate changes in research attitudes and enrollment willingness as a function of time, amyloid result type (elevated\/not elevated), and their interaction.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The reasons most frequently endorsed for wanting to learn amyloid PET result was a \u201cdesire to contribute to research on Alzheimer's disease dementia\u201d and \u201cto inform preventative measures [one] might take (e.g., change diet, exercise, or other lifestyle changes).\u201d Overall, participants reported understanding the results and found learning them useful. Satisfaction with the study visits was overwhelmingly high, with over 80% agreeing with visit usefulness and their satisfaction. Few differences were found between participants who learned an elevated and not elevated result. Over the course of the study, participants who learned an elevated amyloid PET result reported higher willingness to enroll in drug trials (beta: 0.12,\n p<\/jats:italic>\n \u00a0=\u00a00.01) and lifestyle interventions (beta: 0.10,\n p<\/jats:italic>\n \u00a0=\u00a00.02) compared to participants who learned a not elevated result.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Formal incorporation of disclosure practices may encourage participant recruitment and retention within AD research.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Participants wanted to learn their amyloid results to contribute to research.<\/jats:p>\n <\/jats:list-item>\n \n Satisfaction with disclosure and post\u2010disclosure visits was high overall.<\/jats:p>\n <\/jats:list-item>\n \n Returning AD biomarkers can increase willingness to participate in research.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/trc2.12483","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:45:19Z","timestamp":1718347519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Communicating Alzheimer's biomarker results to cognitively unimpaired research participants: Satisfaction, utility, and impact on research attitudes"],"prefix":"10.1002","volume":"10","author":[{"given":"Claire M.","family":"Erickson","sequence":"first","affiliation":[{"name":"Department of Medical Ethics and Health Policy University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred B.","family":"Ketchum","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health Madison USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin E.","family":"Basche","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatrics & Gerontology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel A.","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatrics & Gerontology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella L.","family":"Eveler","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatrics & Gerontology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatrics & Gerontology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"},{"name":"Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12737"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12150"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12213"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000490"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215710"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220861"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001027\u20102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31815a9dcc"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229137"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12413"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100398\u20103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220810"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.11.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51414"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1525\/jer.2011.6.1.63"},{"key":"e_1_2_7_20_1","unstructured":"R: The R Project for Statistical Computing. 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