{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:53:43Z","timestamp":1761483223658,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARGD\u2010591030"],"award-info":[{"award-number":["AARGD\u2010591030"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054671","RM1NS132996"],"award-info":[{"award-number":["R01AG054671","RM1NS132996"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Physical activity (PA) has been linked to reduced Alzheimer's disease (AD) risk. However, less is known about its effects in the AD preclinical stage. We aimed to investigate whether greater PA was associated with lower plasma biomarkers of AD pathology, neural injury, reactive astrocytes, and better cognition in individuals with autosomal\u2010dominant AD due to the presenilin\u20101 E280A mutation who are virtually guaranteed to develop dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight cognitively unimpaired mutation carriers (ages x\u0304 = 29.28) wore a FitBit Charge\u20104 for 14 days. We calculated their average steps to measure locomotion, and Training Impulse (TRIMP) to quantify the intensity and duration of PAs using heart rate. Plasma amyloid beta 42\/40 ratio, phosphorylated tau 181, neurofilament light chain, and glial fibrillary acidic protein (GFAP) were measured. Cognition was assessed with the Consortium to Establish a Registry for Alzheimer's Disease word list learning and delayed recall, Trail Making Test Part A, and Wechsler Adult Intelligence Scale\u2010version IV Digit Span Backward. We conducted multiple linear regressions controlling for age, sex, body mass index, and education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no associations among steps or TRIMP with plasma biomarkers or cognition. Greater TRIMP was related to higher GFAP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PA was not associated with cognition or plasma biomarkers. However, greater intensity and duration of PAs were related to higher GFAP. Participants engaged very little in moderate to vigorous PA. Therefore, light PA may not exert a significant protective effect in preclinical AD. Future work with larger samples and longitudinal data is needed to elucidate further the potential impact of PA on AD progression in the preclinical stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Locomotion (average steps) was not associated with plasma biomarkers or cognition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Greater training load (training impulse) was related to higher glial fibrillary acidic protein levels in mutation carriers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Light physical activity may not suffice to exert a protective effect on Alzheimer's disease.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70003","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:10:25Z","timestamp":1732788625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal\u2010dominant Alzheimer's disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Edmarie","family":"Guzm\u00e1n\u2010V\u00e9lez","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelys","family":"Rivera\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"University of Puerto Rico\u2010R\u00edo Piedras San Juan Puerto Rico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Fabrega","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo E.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Picard","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory Spaulding Rehabilitation Hospital Cambridge Massachusetts USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Harvard Medical School  Boston, MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Andrew","family":"Taylor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory Spaulding Rehabilitation Hospital Cambridge Massachusetts USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Harvard Medical School  Boston, MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"},{"name":"Department of Neurology, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Alzheimer's Association.2024 Alzheimer's Disease facts and figures.2024;20(5)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01820-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv236"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4907"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113641119"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1769-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101064"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health\u2010related research","volume":"100","author":"Caspersen CJ","year":"1985","journal-title":"Public Health Rep"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005290"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015950108"},{"key":"e_1_2_7_13_1","first-page":"32","article-title":"Plasticity of brain networks in a randomized intervention trial of exercise training in older adults","volume":"2","author":"Voss MW","year":"2010","journal-title":"Front Aging Neurosci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.1.62"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01110-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00061"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22096"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.9.1027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182535d35"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1879"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000964"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3059"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-5-56"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4851"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02012-w"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad229"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac613"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0663-1"},{"issue":"3","key":"e_1_2_7_29_1","first-page":"170","article-title":"Planning for future performance: implications for long term training","volume":"5","author":"Banister EW","year":"1980","journal-title":"Can J Appl Sport Sci"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2014.922621"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2016-0403"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12724"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008081"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01709-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12248"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01137-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30137-X"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13314"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610292001157"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.0.CO;2-H"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282162"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2196\/18694"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244893"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1675"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01130-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27702-w"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12301"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01148-0"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.7043"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2196\/45103"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:46:49Z","timestamp":1761482809000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/trc2.70003"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70003","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"type":"print","value":"2352-8737"},{"type":"electronic","value":"2352-8737"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70003"}}