{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:20:41Z","timestamp":1791397241569,"version":"4.3.3"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results. In this systematic review and meta\u2010analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty\u2010five observational studies including over 7 million patients were analyzed. Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88). Additionally, rosuvastatin demonstrated the most pronounced protective effect for all\u2010cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention. Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results. Future randomized clinical trials are necessary to confirm these findings and enlighten clinical guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Largest meta\u2010analysis to date on statins and dementia risk, including 55 studies and more than 7 million patients.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Statin use linked to lower risks of all\u2010dementia, AD, and VaD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Numerous significant subgroup results highlight statins' diverse neuroprotective effects.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings support statins as a public health tool, especially in low\u2010income countries.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Future research should explore the impact of statins across diverse patient populations.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70039","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:11:44Z","timestamp":1737007904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Statin use and dementia risk: A systematic review and updated meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3760-673X","authenticated-orcid":false,"given":"Fernando Luiz","family":"Westphal Filho","sequence":"first","affiliation":[{"name":"Department of Clinical Surgery School of Medicine Federal University of Amazonas Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Moss Lopes","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery School of Medicine Federal University of Amazonas Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Menegaz de Almeida","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Mato Grosso Sinop, Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Kendi Tsuchiya","family":"Sano","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Acre Rio Branco Acre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Moraes","family":"Tamashiro","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oc\u00edlio Ribeiro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Piau\u00ed Teresina Piaui Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Cezar Aquino","family":"de Moraes","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Par\u00e1 Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Kreuz","sequence":"additional","affiliation":[{"name":"School of Medicine Lutheran University of Brazil Canoas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francinny Alves","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Hypertension Dante Pazzanese Institute of Cardiology S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Vin\u00edcius","family":"Silveira Feitoza","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery School of Medicine Federal University of Amazonas Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30367\u20106"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.8522"},{"key":"e_1_2_14_4_1","volume-title":"Dementia WHO","author":"World Health 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