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We discuss the design, rationale, and implementation of a pilot feasibility, double\u2010blind, randomized placebo\u2010controlled trial (RCT) examining whether lithium can delay cognitive decline in older adults with mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The study launched in September 2017. The goal was to enroll 80 community\u2010dwelling participants \u2265 60 years with MCI into an RCT in which they would participate for 2 years with baseline and follow\u2010up assessment of cognition, brain imaging, and plasma\u2010based biomarkers. Participants were randomized to lithium or placebo (1:1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We enrolled 80 MCI older adults into the RCT. Baseline characteristics included a mean (standard deviation) age of 72 (7.7) years with 35 male and 45 female participants. Seventy\u2010five participants had positron emission tomography imaging for amyloid beta (A\u03b2), and 66 completed 7T magnetic resonance imaging. Twenty\u2010one participants were A\u03b2+ and 54 were A\u03b2\u2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The study successfully enrolled 80 participants into an RCT examining whether lithium delays cognitive decline. The main study results will be forthcoming.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>NCT03185208.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Eighty adults \u2265 60 years with mild cognitive impairment entered a placebo\u2010controlled randomized controlled trial evaluating lithium's neuroprotective properties.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Participants were followed for 2 years with baseline and follow\u2010up evaluations at 1 and 2 years that included neurocognitive assessment, ultra\u2010high\u2010field structural neuroimaging, positron emission tomography imaging for amyloid beta and tau, and plasma\u2010based biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Study results will be forthcoming.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70112","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:40:21Z","timestamp":1750135221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-988X","authenticated-orcid":false,"given":"Ariel 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