{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:53:36Z","timestamp":1781924016830,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017142","name":"Gruppo Nazionale per il Calcolo Scientifico","doi-asserted-by":"publisher","award":["T32 AG078114"],"award-info":[{"award-number":["T32 AG078114"]}],"id":[{"id":"10.13039\/100017142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50HD105353"],"award-info":[{"award-number":["P50HD105353"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG085730"],"award-info":[{"award-number":["F31AG085730"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG083130"],"award-info":[{"award-number":["K01AG083130"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG070028"],"award-info":[{"award-number":["R01AG070028"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG051406"],"award-info":[{"award-number":["U01AG051406"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG068054"],"award-info":[{"award-number":["U19AG068054"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072973"],"award-info":[{"award-number":["P30AG072973"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG078114"],"award-info":[{"award-number":["T32AG078114"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Adults with Down syndrome (DS) are at risk for Alzheimer's disease (AD). Lifestyle factors such as engagement in moderate\u2010to\u2010vigorous physical activity (MVPA) reduce risk or delay the onset of AD. This study aimed to determine whether MVPA confers a\n                      <jats:italic>resistance<\/jats:italic>\n                      (AD pathology) or\n                      <jats:italic>resilience<\/jats:italic>\n                      (cognitive decline) effect on the relationship between AD pathology and cognitive decline in DS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Analyses included 69 adults with DS (aged 26\u201358) who participated in a longitudinal study across 3.29 years. An actigraphy accelerometer assessed MVPA across 7 days. Directly administered and informant\u2010reported measures assessed cognitive functioning, specifically memory and dementia symptoms. Neuroimaging biomarkers quantified amyloid beta (A\u03b2) burden, as assessed via positron emission tomography imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In regression models, baseline MVPA was not associated with baseline level or change in global A\u03b2 burden across 32 months. However, baseline MVPA (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.005 to \u22120.004,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) significantly moderated the association between increases in A\u03b2 burden and declines in cognitive functioning. Adults with DS who engaged in greater MVPA experienced less cognitive decline compared to adults with DS who engaged in less MVPA, who had similar A\u03b2 load.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>MVPA may help maintain cognitive functioning early in the progression of AD pathology in adults with DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Adults with Down syndrome are genetically at risk for Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Timing of AD clinical onset spans 30+ years.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity has been linked to less cognitive decline and dementia symptoms.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity may protect against dementia through resilience mechanisms.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity could be a low\u2010cost intervention to help prevent cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70127","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:34:52Z","timestamp":1751070892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-294X","authenticated-orcid":false,"given":"Victoria L.","family":"Fleming","sequence":"first","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Department of Human Development and Family Studies University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Peven","sequence":"additional","affiliation":[{"name":"Behavioral Health Service Line VA Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Helsel","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Ptomey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne","family":"Clina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlyn","family":"Barry","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M.","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Christian","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Department of Psychiatry University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Laymon","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Zammit","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Irvine School of Medicine University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology Irvine School of Medicine University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigan L.","family":"Hartley","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Department of Human Development and Family Studies University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer Biomarkers Consortium \u2013 Down Syndrome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.113061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061765"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.04.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13534"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182535d35"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102013\u2010092993"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010019\u20101175\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70291\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3059"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170111145817"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.01.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.01.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.01.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000964"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.03.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20398"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1879"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000843"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512799015019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00245\u20103"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102677"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12390"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.12910"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091882"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2018.02.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12065"},{"key":"e_1_2_8_31_1","first-page":"249","volume-title":"The Stanford Binet Intelligence Scales, Fifth Edition","author":"Roid GH","year":"2012"},{"key":"e_1_2_8_32_1","volume-title":"Kaufman Brief Intelligence Test, Second Edition (KBIT-2)","author":"Kaufman AS","year":"2004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102788.2002.00417.x"},{"key":"e_1_2_8_34_1","volume-title":"Dementia questionnaire for people with intellectual disabilities (DMR)","author":"Evenhuis HM","year":"2006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.05.019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895\u20108017(2004)109<98:EOSTFD>2.0.CO;2"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12361"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12075"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12074"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31815a51b3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768\u2010199805000\u201000021"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.571"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158713"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1496462"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101108"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21990"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160836"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.13002"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.70127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:55:03Z","timestamp":1780635303000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/trc2.70127"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70127","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70127"}}