{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:47:00Z","timestamp":1788900420967,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Increasingly, studies are demonstrating language and communication improvement after behavioral interventions for primary progressive aphasia (PPA), and the caregiver perspective has been highlighted as critically important to determining treatment success in this population. This is an exploratory study investigating a comprehensive, person\u2010centered intervention promoting everyday communication, functional independence, and quality of life for people with PPA (PwPPA) and their caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Four intervention programs were run separately in 6 to 8 week blocks with a total of 14 dyads (PwPPA and caregiver) enrolled. Group sessions lasted 2\u00a0hours and included communication strategy training, PPA education from multidisciplinary experts, speech therapy for PwPPA, and a support group for caregivers (blocks 1 and 2). Personalized language exercises were assigned for home practice, using apps or paper\u2010and\u2010pencil tasks. Quantitative and qualitative outcomes were measured before and after each treatment block and included: the Revised Western Aphasia Battery (WAB\u2010R) Aphasia Quotient (AQ) and subtest scores, content information units (CIUs) on the WAB\u2010R picture description task, and qualitative content analysis of semi\u2010structured interviews, gathered from both PwPPA and caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      No statistically significant changes were noted in mean WAB\u2010AQ score pre\u2010 to post\u2010intervention. Mean CIUs produced on the WAB\u2010R picture description task pre\u2010 to post\u2010intervention increased and approached significance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a02.7; confidence interval: \u22120.45, 5.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.09). Qualitative findings from PwPPA and caregivers were very positive, and underscored the sense of community, improved language, communication, and well\u2010being, and access to multidisciplinary expertise and resources afforded by the program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Further investigation into the most appropriate assessment tools and intervention approaches for PPA is warranted and has the potential to make a significant positive impact on PwPPA and their families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We combined quantitative and qualitative measures of efficacy in treating primary progressive aphasia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Language skills were maintained and communication improvement approached significance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Participants noted the benefits of peer support, education, and communication practice.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70132","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T09:45:36Z","timestamp":1753177536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive intervention combining group and personalized language therapy in primary progressive aphasia: Quantitative and qualitative findings"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-6514","authenticated-orcid":false,"given":"Tijana","family":"Simic","sequence":"first","affiliation":[{"name":"Department of Speech\u2010Language Pathology University of Toronto  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehab University Health Network  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Laird","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology University of Toronto  Toronto Ontario Canada"},{"name":"AGE\u2010WELL National Center for Excellence KITE\u2010University Health Network  Toronto Ontario 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