{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:36Z","timestamp":1792510236322,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG054073"],"award-info":[{"award-number":["R01AG054073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG070862"],"award-info":[{"award-number":["R01AG070862"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG058533"],"award-info":[{"award-number":["R01AG058533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB015922"],"award-info":[{"award-number":["P41EB015922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Health and Aging Brain Study\u2013Health Disparities (HABS\u2010HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description\u00a0of the cohort baseline characteristics and outlines the study methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed available data\u00a0from\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01066 non\u2010Hispanic Black (NHB),\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01425 Hispanic, and\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01349 non\u2010Hispanic White (NHW) partners who were actively enrolled in HABS\u2010HD.\u00a0Descriptive statistics are presented for each racial\/ethnic group across demographic, medical, and diagnostic characteristics. Differences in select amyloid (A), tau (T), and neurodegenerative (N) biomarkers spanning proteomic and neuroimaging were examined along with groupwise differences for cognitive test performance and select social determinants of health (SDoH) factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The characteristics of the cohort revealed significant groupwise differences in age, education, sex, and cognitive diagnosis. Higher rates of cognitive impairment (mild cognitive impairment [MCI] and dementia) were found in NHB and Hispanic compared to NHW partners, despite the latter group being older. There were also higher rates of hypertension and diabetes among NHB and Hispanic compared to NHW partners.\u00a0Differences were also found across many plasma (A\/T[N]) biomarkers and select neuroimaging measures, including meta\u2010region of interest and white matter hyperintensities. Positron emission tomography amyloid positivity rates (but not tau positivity) were found to differ, with higher rates observed among NHW (15% amyloid positivity) compared to NHB (3%) partners. Groups also differed by select SDoH factors, including household income, insurance, having a health\u2010care provider, and Area Deprivation Index. All cognitive measures also revealed groupwise differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The baseline cohort characteristics for HABS\u2010HD reveal significant group differences spanning demographic, medical, cognitive, and biological factors (including A\/T[N] biomarkers), which are all critical to understand as they relate to aging and age\u2010related diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The Health and Aging Brain Study\u2013Health Disparities (HABS\u2010HD) cohort baseline characteristics and study methodology were provided.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cohort characteristic differences were found across demographic factors, including age, education, sex, and cognitive diagnosis across the representative groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Biomarkers for amyloid\/tau\/neurodegeneration spanning blood and neuroimaging were shown to differ as well across cohort groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Positivity rates for amyloid positron emission tomography were lower for non\u2010Hispanic Black partners in the cohort compared to non\u2010Hispanic White partners.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70140","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:06:03Z","timestamp":1754985963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Health and Aging Brain Study\u2013Health Disparities (HABS\u2010HD) methods and partner characteristics"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3920-5877","authenticated-orcid":false,"given":"Melissa E.","family":"Petersen","sequence":"first","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Community Health College of Public Health University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Phillips","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Microbiology, Immunology &amp; Genetics, College of Biomedical and Translational Sciences University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin L.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Borzage","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Alfred E. Mann Department of Biomedical Engineering \u00a0Viterbi School of Engineering University of Southern California  Los Angeles California USA"},{"name":"Department of Regulatory and Quality Sciences Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith N.","family":"Braskie","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Shi","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Vintimilla","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Casas","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Barber","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Johnson","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, School of Medicine University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sid E.","family":"O'Bryant","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the HABS\u2010HD Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12202"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20100500\u20107\u201029\/TABLES\/3"},{"key":"e_1_2_9_5_1","first-page":"A118","article-title":"The rapid assessment of physical activity (RAPA) among older adults","volume":"3","author":"Topolski TD","year":"2006","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_9_6_1","unstructured":"Social Determinants of Health | Public Health Gateway | CDC n.d. Accessed June 5 2025.https:\/\/www.cdc.gov\/public\u2010health\u2010gateway\/php\/about\/social\u2010determinants\u2010of\u2010health.html"},{"key":"e_1_2_9_7_1","unstructured":"TUG Test n.d. Accessed December 13 2020.https:\/\/www.cdc.gov\/steadi\/pdf\/TUG_Test\u2010print.pdf"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPHYS.2017.04.002"},{"key":"e_1_2_9_9_1","unstructured":"Short Physical Performance Battery (SPPB) | National Institute on Aging n.d. Accessed December 13 2020.https:\/\/www.nia.nih.gov\/research\/resource\/short\u2010physical\u2010performance\u2010battery\u2010sppb"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_11_1","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2014.918543"},{"key":"e_1_2_9_13_1","volume-title":"WMS\u2010IV: Weschler Memory Scale","author":"Weschler D","year":"2009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1076\/clin.16.4.439.13908"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(82)90033\u20104"},{"key":"e_1_2_9_16_1","article-title":"Clinical dementia rating (CDR)","author":"Berg L","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.8.1091"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.34.7.939"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHNEUROL.2010.115"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/DAD2.12267"},{"key":"e_1_2_9_21_1","unstructured":"CHMP.ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS n.d."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010020\u201004923\u20107"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.08.099"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/TRC2.70045"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.2517\u20106161.1995.TB02031.X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPROT.2010.116"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG1847"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.0020190"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010240633"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/DAD2.12518"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011599"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.122"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.124"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2024.102507"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u20102012\u2010121420"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220300"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001088"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.70140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:55:46Z","timestamp":1780635346000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/trc2.70140"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70140","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70140"}}